Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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[Homology]
Score
Msil_1969PFAM: heat shock protein DnaJ domain protein; KEGG: nha:Nham_0592 hypothetical protein. (258 aa)    
Predicted Functional Partners:
Msil_2723
Beta-ketoacyl synthase; PFAM: short-chain dehydrogenase/reductase SDR; phosphopantetheine-binding; Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; Methyltransferase type 12; KR domain protein; Beta-ketoacyl synthase; Acyl transferase; KEGG: bid:Bind_1113 beta-ketoacyl synthase.
  
 
 0.858
Msil_2751
PFAM: NADH dehydrogenase (ubiquinone) 24 kDa subunit; Respiratory-chain NADH dehydrogenase domain 51 kDa subunit; KEGG: hch:HCH_00108 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit.
    
  0.825
Msil_1248
TIGRFAM: amino acid adenylation domain protein; PFAM: AMP-dependent synthetase and ligase; phosphopantetheine-binding; KEGG: npu:Npun_R6591 amino acid adenylation domain-containing protein.
    
 
 0.801
Msil_1968
KEGG: nha:Nham_0591 hypothetical protein.
       0.773
Msil_1970
PFAM: TRAG family protein; KEGG: nha:Nham_0593 TraG protein.
       0.773
htpG
Heat shock protein Hsp90; Molecular chaperone. Has ATPase activity.
  
 0.694
grpE
GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
  
 
 0.693
Msil_1972
KEGG: nha:Nham_0594 hypothetical protein.
  
 0.679
Msil_0674
KEGG: bid:Bind_2935 HSP70 family molecular chaperone.
  
 0.670
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 0.670
Your Current Organism:
Methylocella silvestris
NCBI taxonomy Id: 395965
Other names: M. silvestris BL2, Methylocella silvestris BL2, Methylocella silvestris str. BL2, Methylocella silvestris strain BL2, Methylocella sp. BL2
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