STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Msil_2197Exonuclease III-like protein; KEGG: mes:Meso_1085 exodeoxyribonuclease III. (126 aa)    
Predicted Functional Partners:
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.807
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
  
 0.719
Msil_0330
TIGRFAM: exodeoxyribonuclease III Xth; PFAM: Endonuclease/exonuclease/phosphatase; KEGG: bid:Bind_0444 exodeoxyribonuclease III Xth.
  
     0.711
Msil_3705
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.674
Msil_3124
PFAM: HhH-GPD family protein; KEGG: met:M446_4878 HhH-GPD family protein.
  
 0.599
Msil_1600
A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.
    
 0.579
Msil_2237
Pseudouridine synthase; PFAM: RNA-binding S4 domain protein; pseudouridine synthase; KEGG: pzu:PHZ_c2300 ribosomal small subunit pseudouridine synthase A; Belongs to the pseudouridine synthase RsuA family.
  
    0.542
Msil_2874
PFAM: RNA-binding S4 domain protein; pseudouridine synthase; KEGG: mex:Mext_3861 RNA-binding S4 domain protein; Belongs to the pseudouridine synthase RsuA family.
  
    0.542
Msil_1307
Transcriptional regulator, AraC family; TIGRFAM: methylated-DNA/protein-cysteine methyltransferase; PFAM: helix-turn-helix- domain containing protein AraC type; Ada metal-binding domain protein; Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding; KEGG: sus:Acid_4009 DNA-O6-methylguanine--protein-cysteine S-methyltransferase / transcriptional regulator Ada.
     
 0.505
Msil_0542
SMART: AAA ATPase; KEGG: bid:Bind_1535 putative DNA polymerase III delta prime subunit.
   
  0.427
Your Current Organism:
Methylocella silvestris
NCBI taxonomy Id: 395965
Other names: M. silvestris BL2, Methylocella silvestris BL2, Methylocella silvestris str. BL2, Methylocella silvestris strain BL2, Methylocella sp. BL2
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.