Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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Score
Msil_3326TIGRFAM: formate dehydrogenase, beta subunit; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; Formate dehydrogenase transmembrane domain protein; KEGG: mrd:Mrad2831_1091 formate dehydrogenase, beta subunit. (302 aa)    
Predicted Functional Partners:
Msil_3325
Contains selenocysteine; TIGRFAM: formate dehydrogenase, alpha subunit; PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region; KEGG: sme:SMa0002 formate dehydrogenase, major subunit (formate dehydrogenase alpha subunit).
 
 0.999
Msil_3327
TIGRFAM: formate dehydrogenase, gamma subunit; KEGG: oan:Oant_2865 formate dehydrogenase, gamma subunit.
 
 0.999
fdhE
Formate dehydrogenase accessory protein FdhE; Necessary for formate dehydrogenase activity. Belongs to the FdhE family.
 
  
 0.966
Msil_3656
TIGRFAM: formate dehydrogenase, alpha subunit; PFAM: ferredoxin; 4Fe-4S ferredoxin iron-sulfur binding domain protein; molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region; 4Fe-4S ferredoxin, iron-sulphur binding, conserved site; KEGG: xau:Xaut_3479 formate dehydrogenase, alpha subunit.
  
 
 0.964
Msil_3654
PFAM: NADH dehydrogenase (ubiquinone) 24 kDa subunit; KEGG: acr:Acry_0841 NADH dehydrogenase (ubiquinone), 24 kDa subunit.
  
 
 0.907
Msil_3655
PFAM: Respiratory-chain NADH dehydrogenase domain 51 kDa subunit; KEGG: smd:Smed_2898 NADH dehydrogenase (quinone).
  
 
 0.906
Msil_2417
KEGG: esa:ESA_02347 hypothetical protein; TIGRFAM: oxidoreductase alpha (molybdopterin) subunit; PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
  
 
 0.901
Msil_2451
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.
     
 0.900
Msil_3658
KEGG: bja:bsl3134 putative NAD-dependent formate dehydrogenase.
     
  0.900
tuf
Translation elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.
  
 
 0.888
Your Current Organism:
Methylocella silvestris
NCBI taxonomy Id: 395965
Other names: M. silvestris BL2, Methylocella silvestris BL2, Methylocella silvestris str. BL2, Methylocella silvestris strain BL2, Methylocella sp. BL2
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