Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
Msil_3756KEGG: bbt:BBta_0468 hypothetical protein. (74 aa)    
Predicted Functional Partners:
Msil_3757
KEGG: bbt:BBta_0467 hypothetical protein.
       0.810
Msil_3754
PFAM: NHL repeat containing protein; KEGG: bbt:BBta_0470 hypothetical protein.
       0.794
Msil_3755
PFAM: nitrogen-fixing NifU domain protein; Rieske [2Fe-2S] domain protein; KEGG: bbt:BBta_0469 putative nitrogen-fixing NifU, Rieske (2Fe-2S) region.
       0.790
Msil_3753
(NiFe) hydrogenase maturation protein HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
       0.786
Msil_3752
TIGRFAM: hydrogenase assembly chaperone hypC/hupF; PFAM: hydrogenase expression/formation protein (HUPF/HYPC); KEGG: ter:Tery_0794 hydrogenase assembly chaperone HypC/HupF.
       0.785
Msil_3758
KEGG: bbt:BBta_0466 hypothetical protein.
       0.682
Msil_3750
TIGRFAM: hydrogenase expression/formation protein HypE; PFAM: AIR synthase related protein; AIR synthase related protein domain protein; KEGG: bbt:BBta_0475 hydrogenase maturation.
       0.607
Msil_3751
TIGRFAM: hydrogenase expression/formation protein HypD; PFAM: hydrogenase formation HypD protein; KEGG: bbt:BBta_0474 hydrogenase expression/formation; Belongs to the HypD family.
       0.607
hypA-2
Hydrogenase expression/synthesis HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
       0.575
Msil_3748
TIGRFAM: hydrogenase accessory protein HypB; PFAM: cobalamin synthesis protein P47K; KEGG: bbt:BBta_0478 hydrogenase nickel incorporation.
       0.557
Your Current Organism:
Methylocella silvestris
NCBI taxonomy Id: 395965
Other names: M. silvestris BL2, Methylocella silvestris BL2, Methylocella silvestris str. BL2, Methylocella silvestris strain BL2, Methylocella sp. BL2
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