STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pyrC-1Dihydroorotase 1; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (348 aa)    
Predicted Functional Partners:
pyrB
Aspartate carbamoyltransferase catalytic subunit; Protein involved in carboxyl- or carbamoyltransferase activity and cellular amino acid metabolic process; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
   
 
 0.986
pyrD
Dihydroorotate dehydrogenase (quinone); Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
 
 
 0.984
pyrC-2
Dihydroorotase 2; Protein involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds.
    
 0.914
preA
Dihydropyrimidine dehydrogenase subunit PreA; Protein involved in electron carrier activity, iron-sulfur cluster binding, UMP biosynthetic process and oxidation-reduction process.
  
  
 0.830
carA
Carbamoyl phosphate synthetase small subunit; Belongs to the CarA family.
   
  
 0.674
ANL60831.1
Sensor histidine kinase protein; Protein involved in signal transducer activity, protein histidine kinase activity, signal transduction and peptidyl-histidine phosphorylation.
   
    0.667
carB
Carbamoyl phosphate synthetase large subunit; Protein involved in ATP binding, ligase activity and nitrogen compound metabolic process; Belongs to the CarB family.
   
  
 0.663
ANL58992.1
Carbamoyl phosphate synthetase large subunit protein; Protein involved in ATP binding and ligase activity.
   
  
 0.660
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
   
  
 0.650
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
 
 
 0.620
Your Current Organism:
Rhizobium phaseoli
NCBI taxonomy Id: 396
Other names: ATCC 14482, DSM 30137, IFO 14785, JCM 20683, NBRC 14785, NRRL L-321, R. phaseoli
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