| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANL58978.1 | hemB | AMC85_CH01568 | AMC85_CH01567 | Hypothetical protein. | Delta-aminolevulinic acid dehydratase; Protein involved in catalytic activity, metal ion binding and tetrapyrrole biosynthetic process; Belongs to the ALAD family. | 0.714 |
| cobA | cobB | AMC85_CH02579 | AMC85_CH02578 | uroporphyrinogen-III C-methyltransferase; Protein involved in methyltransferase activity, precorrin-2 dehydrogenase activity, metabolic process and oxidation-reduction process; Belongs to the precorrin methyltransferase family. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.965 |
| cobA | cysG | AMC85_CH02579 | AMC85_CH02094 | uroporphyrinogen-III C-methyltransferase; Protein involved in methyltransferase activity, precorrin-2 dehydrogenase activity, metabolic process and oxidation-reduction process; Belongs to the precorrin methyltransferase family. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.971 |
| cobA | hemB | AMC85_CH02579 | AMC85_CH01567 | uroporphyrinogen-III C-methyltransferase; Protein involved in methyltransferase activity, precorrin-2 dehydrogenase activity, metabolic process and oxidation-reduction process; Belongs to the precorrin methyltransferase family. | Delta-aminolevulinic acid dehydratase; Protein involved in catalytic activity, metal ion binding and tetrapyrrole biosynthetic process; Belongs to the ALAD family. | 0.926 |
| cobA | hemC | AMC85_CH02579 | AMC85_CH04167 | uroporphyrinogen-III C-methyltransferase; Protein involved in methyltransferase activity, precorrin-2 dehydrogenase activity, metabolic process and oxidation-reduction process; Belongs to the precorrin methyltransferase family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.994 |
| cobA | hemD | AMC85_CH02579 | AMC85_CH04168 | uroporphyrinogen-III C-methyltransferase; Protein involved in methyltransferase activity, precorrin-2 dehydrogenase activity, metabolic process and oxidation-reduction process; Belongs to the precorrin methyltransferase family. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.962 |
| cobA | hemE | AMC85_CH02579 | AMC85_CH04403 | uroporphyrinogen-III C-methyltransferase; Protein involved in methyltransferase activity, precorrin-2 dehydrogenase activity, metabolic process and oxidation-reduction process; Belongs to the precorrin methyltransferase family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.922 |
| cobB | cobA | AMC85_CH02578 | AMC85_CH02579 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | uroporphyrinogen-III C-methyltransferase; Protein involved in methyltransferase activity, precorrin-2 dehydrogenase activity, metabolic process and oxidation-reduction process; Belongs to the precorrin methyltransferase family. | 0.965 |
| cobB | cysG | AMC85_CH02578 | AMC85_CH02094 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.808 |
| cobB | hemB | AMC85_CH02578 | AMC85_CH01567 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Delta-aminolevulinic acid dehydratase; Protein involved in catalytic activity, metal ion binding and tetrapyrrole biosynthetic process; Belongs to the ALAD family. | 0.669 |
| cobB | hemC | AMC85_CH02578 | AMC85_CH04167 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.760 |
| cobB | hemD | AMC85_CH02578 | AMC85_CH04168 | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.579 |
| cysG | cobA | AMC85_CH02094 | AMC85_CH02579 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | uroporphyrinogen-III C-methyltransferase; Protein involved in methyltransferase activity, precorrin-2 dehydrogenase activity, metabolic process and oxidation-reduction process; Belongs to the precorrin methyltransferase family. | 0.971 |
| cysG | cobB | AMC85_CH02094 | AMC85_CH02578 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.808 |
| cysG | hemB | AMC85_CH02094 | AMC85_CH01567 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Delta-aminolevulinic acid dehydratase; Protein involved in catalytic activity, metal ion binding and tetrapyrrole biosynthetic process; Belongs to the ALAD family. | 0.916 |
| cysG | hemC | AMC85_CH02094 | AMC85_CH04167 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.971 |
| cysG | hemD | AMC85_CH02094 | AMC85_CH04168 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.962 |
| cysG | hemE | AMC85_CH02094 | AMC85_CH04403 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.956 |
| cysG | hemH | AMC85_CH02094 | AMC85_CH03732 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.580 |
| hemA-1 | hemB | AMC85_CH04104 | AMC85_CH01567 | 5-aminolevulinate synthase 1; Protein involved in catalytic activity, pyridoxal phosphate binding and tetrapyrrole biosynthetic process. | Delta-aminolevulinic acid dehydratase; Protein involved in catalytic activity, metal ion binding and tetrapyrrole biosynthetic process; Belongs to the ALAD family. | 0.976 |
