STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nrdRTranscriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (158 aa)    
Predicted Functional Partners:
ANL58983.1
Riboflavin biosynthesis protein RibD; Protein involved in oxidoreductase activity, hydrolase activity and oxidation-reduction process.
  
  
 0.913
glyA-1
Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.800
ribE
Riboflavin synthase subunit alpha; Protein involved in oxidoreductase activity and oxidation-reduction process.
     
 0.798
ANL58187.1
XRE family transcriptional regulator protein; Protein involved in DNA binding.
   
  
 0.584
dksA
RNA polymerase-binding protein DksA; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters.
     
 0.584
folC
Bifunctional folylpolyglutamate synthase/dihydrofolate synthase; Protein involved in ATP binding, ligase activity and biosynthetic process; Belongs to the folylpolyglutamate synthase family.
  
   
 0.582
mgsA
Methylglyoxal synthase; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.
     
 0.562
ANL57724.1
XRE family transcriptional regulator protein; Protein involved in DNA binding.
   
  
 0.562
tlyA
Hemolysin protein TlyA; Protein involved in RNA binding, methyltransferase activity and hemolysis by symbiont of host erythrocytes.
  
   
 0.541
hisS
histidyl-tRNA synthetase; Protein involved in nucleotide binding, histidine-tRNA ligase activity, ATP binding and histidyl-tRNA aminoacylation.
      
 0.540
Your Current Organism:
Rhizobium phaseoli
NCBI taxonomy Id: 396
Other names: ATCC 14482, DSM 30137, IFO 14785, JCM 20683, NBRC 14785, NRRL L-321, R. phaseoli
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