| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANL58983.1 | accC-1 | AMC85_CH01573 | AMC85_CH01959 | Riboflavin biosynthesis protein RibD; Protein involved in oxidoreductase activity, hydrolase activity and oxidation-reduction process. | acetyl-CoA carboxylase biotin carboxylase subunit AccC 1; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | 0.863 |
| ANL58983.1 | eno-1 | AMC85_CH01573 | AMC85_CH02053 | Riboflavin biosynthesis protein RibD; Protein involved in oxidoreductase activity, hydrolase activity and oxidation-reduction process. | Enolase 1; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. | 0.932 |
| ANL58983.1 | eno-2 | AMC85_CH01573 | AMC85_CH02310 | Riboflavin biosynthesis protein RibD; Protein involved in oxidoreductase activity, hydrolase activity and oxidation-reduction process. | Enolase 2; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. | 0.932 |
| ANL58983.1 | glyA-1 | AMC85_CH01573 | AMC85_CH01571 | Riboflavin biosynthesis protein RibD; Protein involved in oxidoreductase activity, hydrolase activity and oxidation-reduction process. | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.833 |
| ANL58983.1 | nadD | AMC85_CH01573 | AMC85_CH04345 | Riboflavin biosynthesis protein RibD; Protein involved in oxidoreductase activity, hydrolase activity and oxidation-reduction process. | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.741 |
| ANL58983.1 | nrdR | AMC85_CH01573 | AMC85_CH01572 | Riboflavin biosynthesis protein RibD; Protein involved in oxidoreductase activity, hydrolase activity and oxidation-reduction process. | Transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.922 |
| ANL58983.1 | ribBA-1 | AMC85_CH01573 | AMC85_CH01004 | Riboflavin biosynthesis protein RibD; Protein involved in oxidoreductase activity, hydrolase activity and oxidation-reduction process. | Bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II RibBA 1; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.999 |
| ANL58983.1 | ribE | AMC85_CH01573 | AMC85_CH01574 | Riboflavin biosynthesis protein RibD; Protein involved in oxidoreductase activity, hydrolase activity and oxidation-reduction process. | Riboflavin synthase subunit alpha; Protein involved in oxidoreductase activity and oxidation-reduction process. | 0.999 |
| ANL58983.1 | ribH-1 | AMC85_CH01573 | AMC85_CH01588 | Riboflavin biosynthesis protein RibD; Protein involved in oxidoreductase activity, hydrolase activity and oxidation-reduction process. | 6,7-dimethyl-8-ribityllumazine synthase 1; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.988 |
| ANL58983.1 | ribH-2 | AMC85_CH01573 | AMC85_CH02802 | Riboflavin biosynthesis protein RibD; Protein involved in oxidoreductase activity, hydrolase activity and oxidation-reduction process. | 6,7-dimethyl-8-ribityllumazine synthase 2; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.974 |
| accC-1 | ANL58983.1 | AMC85_CH01959 | AMC85_CH01573 | acetyl-CoA carboxylase biotin carboxylase subunit AccC 1; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | Riboflavin biosynthesis protein RibD; Protein involved in oxidoreductase activity, hydrolase activity and oxidation-reduction process. | 0.863 |
| eno-1 | ANL58983.1 | AMC85_CH02053 | AMC85_CH01573 | Enolase 1; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. | Riboflavin biosynthesis protein RibD; Protein involved in oxidoreductase activity, hydrolase activity and oxidation-reduction process. | 0.932 |
| eno-1 | eno-2 | AMC85_CH02053 | AMC85_CH02310 | Enolase 1; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. | Enolase 2; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. | 0.568 |
| eno-2 | ANL58983.1 | AMC85_CH02310 | AMC85_CH01573 | Enolase 2; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. | Riboflavin biosynthesis protein RibD; Protein involved in oxidoreductase activity, hydrolase activity and oxidation-reduction process. | 0.932 |
| eno-2 | eno-1 | AMC85_CH02310 | AMC85_CH02053 | Enolase 2; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. | Enolase 1; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. | 0.568 |
| glyA-1 | ANL58983.1 | AMC85_CH01571 | AMC85_CH01573 | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Riboflavin biosynthesis protein RibD; Protein involved in oxidoreductase activity, hydrolase activity and oxidation-reduction process. | 0.833 |
| glyA-1 | nrdR | AMC85_CH01571 | AMC85_CH01572 | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.793 |
| glyA-1 | ribBA-1 | AMC85_CH01571 | AMC85_CH01004 | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II RibBA 1; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.634 |
| glyA-1 | ribE | AMC85_CH01571 | AMC85_CH01574 | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Riboflavin synthase subunit alpha; Protein involved in oxidoreductase activity and oxidation-reduction process. | 0.792 |
| nadD | ANL58983.1 | AMC85_CH04345 | AMC85_CH01573 | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Riboflavin biosynthesis protein RibD; Protein involved in oxidoreductase activity, hydrolase activity and oxidation-reduction process. | 0.741 |