| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANL58980.1 | ANL58983.1 | AMC85_CH01570 | AMC85_CH01573 | L,D-transpeptidase domain-containing protein; Protein involved in transferase activity and metabolic process. | Riboflavin biosynthesis protein RibD; Protein involved in oxidoreductase activity, hydrolase activity and oxidation-reduction process. | 0.592 |
| ANL58980.1 | glyA-1 | AMC85_CH01570 | AMC85_CH01571 | L,D-transpeptidase domain-containing protein; Protein involved in transferase activity and metabolic process. | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.480 |
| ANL58980.1 | nrdR | AMC85_CH01570 | AMC85_CH01572 | L,D-transpeptidase domain-containing protein; Protein involved in transferase activity and metabolic process. | Transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.491 |
| ANL58980.1 | ribE | AMC85_CH01570 | AMC85_CH01574 | L,D-transpeptidase domain-containing protein; Protein involved in transferase activity and metabolic process. | Riboflavin synthase subunit alpha; Protein involved in oxidoreductase activity and oxidation-reduction process. | 0.491 |
| ANL58983.1 | ANL58980.1 | AMC85_CH01573 | AMC85_CH01570 | Riboflavin biosynthesis protein RibD; Protein involved in oxidoreductase activity, hydrolase activity and oxidation-reduction process. | L,D-transpeptidase domain-containing protein; Protein involved in transferase activity and metabolic process. | 0.592 |
| ANL58983.1 | folK | AMC85_CH01573 | AMC85_CH02428 | Riboflavin biosynthesis protein RibD; Protein involved in oxidoreductase activity, hydrolase activity and oxidation-reduction process. | 7, 8-dihydro-6-hydroxymethylpterin pyrophosphokinase. | 0.714 |
| ANL58983.1 | folP | AMC85_CH01573 | AMC85_CH02430 | Riboflavin biosynthesis protein RibD; Protein involved in oxidoreductase activity, hydrolase activity and oxidation-reduction process. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.732 |
| ANL58983.1 | glyA-1 | AMC85_CH01573 | AMC85_CH01571 | Riboflavin biosynthesis protein RibD; Protein involved in oxidoreductase activity, hydrolase activity and oxidation-reduction process. | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.833 |
| ANL58983.1 | nrdR | AMC85_CH01573 | AMC85_CH01572 | Riboflavin biosynthesis protein RibD; Protein involved in oxidoreductase activity, hydrolase activity and oxidation-reduction process. | Transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. | 0.922 |
| ANL58983.1 | ribBA-1 | AMC85_CH01573 | AMC85_CH01004 | Riboflavin biosynthesis protein RibD; Protein involved in oxidoreductase activity, hydrolase activity and oxidation-reduction process. | Bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II RibBA 1; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.999 |
| ANL58983.1 | ribE | AMC85_CH01573 | AMC85_CH01574 | Riboflavin biosynthesis protein RibD; Protein involved in oxidoreductase activity, hydrolase activity and oxidation-reduction process. | Riboflavin synthase subunit alpha; Protein involved in oxidoreductase activity and oxidation-reduction process. | 0.999 |
| ANL58983.1 | ribF | AMC85_CH01573 | AMC85_CH00896 | Riboflavin biosynthesis protein RibD; Protein involved in oxidoreductase activity, hydrolase activity and oxidation-reduction process. | Bifunctional riboflavin kinase/FMN adenylyltransferase; Protein involved in riboflavin kinase activity and riboflavin biosynthetic process; Belongs to the ribF family. | 0.703 |
| ANL58983.1 | ribH-1 | AMC85_CH01573 | AMC85_CH01588 | Riboflavin biosynthesis protein RibD; Protein involved in oxidoreductase activity, hydrolase activity and oxidation-reduction process. | 6,7-dimethyl-8-ribityllumazine synthase 1; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.988 |
| ANL58983.1 | ribH-2 | AMC85_CH01573 | AMC85_CH02802 | Riboflavin biosynthesis protein RibD; Protein involved in oxidoreductase activity, hydrolase activity and oxidation-reduction process. | 6,7-dimethyl-8-ribityllumazine synthase 2; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.974 |
| folK | ANL58983.1 | AMC85_CH02428 | AMC85_CH01573 | 7, 8-dihydro-6-hydroxymethylpterin pyrophosphokinase. | Riboflavin biosynthesis protein RibD; Protein involved in oxidoreductase activity, hydrolase activity and oxidation-reduction process. | 0.714 |
| folK | folP | AMC85_CH02428 | AMC85_CH02430 | 7, 8-dihydro-6-hydroxymethylpterin pyrophosphokinase. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.999 |
| folK | ribBA-1 | AMC85_CH02428 | AMC85_CH01004 | 7, 8-dihydro-6-hydroxymethylpterin pyrophosphokinase. | Bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II RibBA 1; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.712 |
| folK | ribE | AMC85_CH02428 | AMC85_CH01574 | 7, 8-dihydro-6-hydroxymethylpterin pyrophosphokinase. | Riboflavin synthase subunit alpha; Protein involved in oxidoreductase activity and oxidation-reduction process. | 0.505 |
| folK | ribF | AMC85_CH02428 | AMC85_CH00896 | 7, 8-dihydro-6-hydroxymethylpterin pyrophosphokinase. | Bifunctional riboflavin kinase/FMN adenylyltransferase; Protein involved in riboflavin kinase activity and riboflavin biosynthetic process; Belongs to the ribF family. | 0.533 |
| folK | ribH-1 | AMC85_CH02428 | AMC85_CH01588 | 7, 8-dihydro-6-hydroxymethylpterin pyrophosphokinase. | 6,7-dimethyl-8-ribityllumazine synthase 1; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.623 |