ntrB protein (Rhizobium phaseoli) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Rhizobium phaseoli

NCBI taxonomy Id: 396
Other names: ATCC 14482, DSM 30137, IFO 14785, JCM 20683, NBRC 14785, NRRL L-321, R. phaseoli

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANL59868.1	amtB	AMC85_CH02500	AMC85_CH04236	Sensor histidine kinase/response regulator hybrid protein; Protein involved in protein binding, signal transduction and regulation of transcription, DNA-dependent.	Protein involved in ammonium transmembrane transporter activity and ammonium transmembrane transport.	0.441
ANL59868.1	ntrB	AMC85_CH02500	AMC85_CH02069	Sensor histidine kinase/response regulator hybrid protein; Protein involved in protein binding, signal transduction and regulation of transcription, DNA-dependent.	Protein involved in signal transducer activity and regulation of transcription, DNA-dependent.	0.849
amtB	ANL59868.1	AMC85_CH04236	AMC85_CH02500	Protein involved in ammonium transmembrane transporter activity and ammonium transmembrane transport.	Sensor histidine kinase/response regulator hybrid protein; Protein involved in protein binding, signal transduction and regulation of transcription, DNA-dependent.	0.441
amtB	glnB-1	AMC85_CH04236	AMC85_CH02174	Protein involved in ammonium transmembrane transporter activity and ammonium transmembrane transport.	Nitrogen regulatory protein P-II GlnB 1; Protein involved in enzyme regulator activity and regulation of nitrogen utilization; Belongs to the P(II) protein family.	0.998
amtB	glnB-2	AMC85_CH04236	AMC85_CH04237	Protein involved in ammonium transmembrane transporter activity and ammonium transmembrane transport.	Nitrogen regulatory protein P-II GlnB 2; Protein involved in enzyme regulator activity and regulation of nitrogen utilization; Belongs to the P(II) protein family.	0.999
amtB	glnD	AMC85_CH04236	AMC85_CH00426	Protein involved in ammonium transmembrane transporter activity and ammonium transmembrane transport.	PII uridylyl-transferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.	0.872
amtB	glnE	AMC85_CH04236	AMC85_CH01381	Protein involved in ammonium transmembrane transporter activity and ammonium transmembrane transport.	Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...]	0.832
amtB	ntrB	AMC85_CH04236	AMC85_CH02069	Protein involved in ammonium transmembrane transporter activity and ammonium transmembrane transport.	Protein involved in signal transducer activity and regulation of transcription, DNA-dependent.	0.863
amtB	ntrC	AMC85_CH04236	AMC85_CH02070	Protein involved in ammonium transmembrane transporter activity and ammonium transmembrane transport.	Nitrogen assimilation regulatory protein NtrC; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.	0.832
dctD	ntrB	AMC85_CH03130	AMC85_CH02069	C4-dicarboxylate transport response regulator DctD; Protein involved in protein binding, nucleoside-triphosphatase activity and regulation of transcription, DNA-dependent.	Protein involved in signal transducer activity and regulation of transcription, DNA-dependent.	0.791
dus	ntrB	AMC85_CH02068	AMC85_CH02069	tRNA-dihydrouridine synthase; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family.	Protein involved in signal transducer activity and regulation of transcription, DNA-dependent.	0.894
dus	ntrC	AMC85_CH02068	AMC85_CH02070	tRNA-dihydrouridine synthase; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family.	Nitrogen assimilation regulatory protein NtrC; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.	0.806
glnB-1	amtB	AMC85_CH02174	AMC85_CH04236	Nitrogen regulatory protein P-II GlnB 1; Protein involved in enzyme regulator activity and regulation of nitrogen utilization; Belongs to the P(II) protein family.	Protein involved in ammonium transmembrane transporter activity and ammonium transmembrane transport.	0.998
glnB-1	glnD	AMC85_CH02174	AMC85_CH00426	Nitrogen regulatory protein P-II GlnB 1; Protein involved in enzyme regulator activity and regulation of nitrogen utilization; Belongs to the P(II) protein family.	PII uridylyl-transferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.	0.978
glnB-1	glnE	AMC85_CH02174	AMC85_CH01381	Nitrogen regulatory protein P-II GlnB 1; Protein involved in enzyme regulator activity and regulation of nitrogen utilization; Belongs to the P(II) protein family.	Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...]	0.414
glnB-1	ntrB	AMC85_CH02174	AMC85_CH02069	Nitrogen regulatory protein P-II GlnB 1; Protein involved in enzyme regulator activity and regulation of nitrogen utilization; Belongs to the P(II) protein family.	Protein involved in signal transducer activity and regulation of transcription, DNA-dependent.	0.979
glnB-2	amtB	AMC85_CH04237	AMC85_CH04236	Nitrogen regulatory protein P-II GlnB 2; Protein involved in enzyme regulator activity and regulation of nitrogen utilization; Belongs to the P(II) protein family.	Protein involved in ammonium transmembrane transporter activity and ammonium transmembrane transport.	0.999
glnB-2	glnD	AMC85_CH04237	AMC85_CH00426	Nitrogen regulatory protein P-II GlnB 2; Protein involved in enzyme regulator activity and regulation of nitrogen utilization; Belongs to the P(II) protein family.	PII uridylyl-transferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.	0.777
glnB-2	ntrB	AMC85_CH04237	AMC85_CH02069	Nitrogen regulatory protein P-II GlnB 2; Protein involved in enzyme regulator activity and regulation of nitrogen utilization; Belongs to the P(II) protein family.	Protein involved in signal transducer activity and regulation of transcription, DNA-dependent.	0.807
glnD	amtB	AMC85_CH00426	AMC85_CH04236	PII uridylyl-transferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.	Protein involved in ammonium transmembrane transporter activity and ammonium transmembrane transport.	0.872