STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cysGSiroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. (478 aa)    
Predicted Functional Partners:
ANL59473.1
Protein involved in oxidoreductase activity, heme binding, iron-sulfur cluster binding and oxidation-reduction process.
 
  
 0.996
cysH
Phosphoadenosine-phosphosulfate reductase; Reduction of activated sulfate into sulfite.
 
  
 0.975
cobA
uroporphyrinogen-III C-methyltransferase; Protein involved in methyltransferase activity, precorrin-2 dehydrogenase activity, metabolic process and oxidation-reduction process; Belongs to the precorrin methyltransferase family.
 
 
0.971
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.964
cysD
Protein involved in sulfate adenylyltransferase (ATP) activity and sulfate reduction.
 
  
 0.959
hemD
uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
  
 
 0.955
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
    
 0.948
ANL59472.1
Hypothetical protein.
 
  
 0.929
hemB
Delta-aminolevulinic acid dehydratase; Protein involved in catalytic activity, metal ion binding and tetrapyrrole biosynthetic process; Belongs to the ALAD family.
 
  
 0.885
nirD
Nitrate reductase (NAD(P)H) large subunit NirD; Protein involved in oxidoreductase activity, 2 iron, 2 sulfur cluster binding and oxidation-reduction process.
  
  
 0.880
Your Current Organism:
Rhizobium phaseoli
NCBI taxonomy Id: 396
Other names: ATCC 14482, DSM 30137, IFO 14785, JCM 20683, NBRC 14785, NRRL L-321, R. phaseoli
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