STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sdaAProtein involved in L-serine ammonia-lyase activity, 4 iron, 4 sulfur cluster binding and gluconeogenesis; Belongs to the iron-sulfur dependent L-serine dehydratase family. (467 aa)    
Predicted Functional Partners:
glyA-1
Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.953
glyA-2
Serine hydroxymethyltransferase 2; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.953
ilvA
Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
  
 
 0.920
ANL60274.1
Protein involved in phosphoserine phosphatase activity and metabolic process.
   
 
 0.920
ANL61044.1
Pyridoxal phosphate-dependent threonine dehydratase protein; Protein involved in catalytic activity, pyridoxal phosphate binding and metabolic process.
  
 
 0.920
ANL61686.1
Pyridoxal phosphate-dependent serine/threonine dehydratase protein; Protein involved in catalytic activity, pyridoxal phosphate binding and metabolic process.
  
 
 0.920
dsdA
D-serine dehydratase; Protein involved in catalytic activity, pyridoxal phosphate binding and metabolic process; Belongs to the serine/threonine dehydratase family. DsdA subfamily.
     
 0.917
cysE-1
Serine O-acetyltransferase 1; Protein involved in transferase activity and cysteine biosynthetic process from serine.
     
 0.912
cysE-2
Serine O-acetyltransferase 2; Protein involved in transferase activity and cysteine biosynthetic process from serine.
     
 0.912
trpA
Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
   
 
 0.904
Your Current Organism:
Rhizobium phaseoli
NCBI taxonomy Id: 396
Other names: ATCC 14482, DSM 30137, IFO 14785, JCM 20683, NBRC 14785, NRRL L-321, R. phaseoli
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