STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fumCFumarate hydratase class 2; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (463 aa)    
Predicted Functional Partners:
sdhA
Succinate dehydrogenase flavoprotein subunit; Protein involved in oxidoreductase activity, flavin adenine dinucleotide binding and oxidation-reduction process; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
 
 0.997
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.
  
 0.983
fumA
Fumarate hydratase class 1; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
  
 
 0.980
tme
NADP-dependent malic enzyme; Protein involved in nucleotide binding, NAD binding and oxidation-reduction process.
  
 
 0.975
dme
Malic enzyme; Protein involved in nucleotide binding, NAD binding and oxidation-reduction process.
  
 
 0.973
sdhB
Succinate dehydrogenase iron-sulfur subunit; Protein involved in electron carrier activity, iron-sulfur cluster binding and oxidation-reduction process; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
  
 0.972
sdhC
Succinate dehydrogenase cytochrome b556 subunit; Protein involved in succinate dehydrogenase activity and tricarboxylic acid cycle.
  
 
 0.970
glcB
Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily.
    
 0.934
sdhD
Protein involved in succinate dehydrogenase activity, heme binding and tricarboxylic acid cycle.
  
 
 0.921
gltA
Citrate synthase; Protein involved in transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer and cellular carbohydrate metabolic process; Belongs to the citrate synthase family.
   
 0.912
Your Current Organism:
Rhizobium phaseoli
NCBI taxonomy Id: 396
Other names: ATCC 14482, DSM 30137, IFO 14785, JCM 20683, NBRC 14785, NRRL L-321, R. phaseoli
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.