STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Cooccurrence
Coexpression
Experiments
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[Homology]
Score
fumAFumarate hydratase class 1; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (535 aa)    
Predicted Functional Partners:
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.
  
 
 0.996
sdhA
Succinate dehydrogenase flavoprotein subunit; Protein involved in oxidoreductase activity, flavin adenine dinucleotide binding and oxidation-reduction process; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
  
 
 0.995
sdhB
Succinate dehydrogenase iron-sulfur subunit; Protein involved in electron carrier activity, iron-sulfur cluster binding and oxidation-reduction process; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
  
 
 0.993
dme
Malic enzyme; Protein involved in nucleotide binding, NAD binding and oxidation-reduction process.
  
 
 0.988
sdhC
Succinate dehydrogenase cytochrome b556 subunit; Protein involved in succinate dehydrogenase activity and tricarboxylic acid cycle.
  
 
 0.988
sdhD
Protein involved in succinate dehydrogenase activity, heme binding and tricarboxylic acid cycle.
  
 
 0.984
fumC
Fumarate hydratase class 2; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  
 
 0.982
icd
Isocitrate dehydrogenase (NADP(+)); Protein involved in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor and oxidation-reduction process; Belongs to the isocitrate and isopropylmalate dehydrogenases family.
  
  
 0.973
gltA
Citrate synthase; Protein involved in transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer and cellular carbohydrate metabolic process; Belongs to the citrate synthase family.
  
 
 0.967
gcvP
Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
   
  
 0.967
Your Current Organism:
Rhizobium phaseoli
NCBI taxonomy Id: 396
Other names: ATCC 14482, DSM 30137, IFO 14785, JCM 20683, NBRC 14785, NRRL L-321, R. phaseoli
Server load: medium (52%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.