Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| fhs | folA | AMC85_CH03226 | AMC85_CH02917 | Protein involved in formate-tetrahydrofolate ligase activity, ATP binding and folic acid-containing compound biosynthetic process; Belongs to the formate--tetrahydrofolate ligase family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.920 |
| fhs | folD-1 | AMC85_CH03226 | AMC85_CH00743 | Protein involved in formate-tetrahydrofolate ligase activity, ATP binding and folic acid-containing compound biosynthetic process; Belongs to the formate--tetrahydrofolate ligase family. | Bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase FolD 1; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.997 |
| fhs | folD-2 | AMC85_CH03226 | AMC85_CH02085 | Protein involved in formate-tetrahydrofolate ligase activity, ATP binding and folic acid-containing compound biosynthetic process; Belongs to the formate--tetrahydrofolate ligase family. | Bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase FolD 2; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.997 |
| fhs | gcvT | AMC85_CH03226 | AMC85_CH02346 | Protein involved in formate-tetrahydrofolate ligase activity, ATP binding and folic acid-containing compound biosynthetic process; Belongs to the formate--tetrahydrofolate ligase family. | Protein involved in aminomethyltransferase activity and glycine catabolic process. | 0.934 |
| fhs | glyA-1 | AMC85_CH03226 | AMC85_CH01571 | Protein involved in formate-tetrahydrofolate ligase activity, ATP binding and folic acid-containing compound biosynthetic process; Belongs to the formate--tetrahydrofolate ligase family. | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.957 |
| fhs | glyA-2 | AMC85_CH03226 | AMC85_CH02084 | Protein involved in formate-tetrahydrofolate ligase activity, ATP binding and folic acid-containing compound biosynthetic process; Belongs to the formate--tetrahydrofolate ligase family. | Serine hydroxymethyltransferase 2; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.957 |
| fhs | metH | AMC85_CH03226 | AMC85_CH03036 | Protein involved in formate-tetrahydrofolate ligase activity, ATP binding and folic acid-containing compound biosynthetic process; Belongs to the formate--tetrahydrofolate ligase family. | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.951 |
| fhs | purF | AMC85_CH03226 | AMC85_CH01490 | Protein involved in formate-tetrahydrofolate ligase activity, ATP binding and folic acid-containing compound biosynthetic process; Belongs to the formate--tetrahydrofolate ligase family. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.846 |
| fhs | purH | AMC85_CH03226 | AMC85_CH04383 | Protein involved in formate-tetrahydrofolate ligase activity, ATP binding and folic acid-containing compound biosynthetic process; Belongs to the formate--tetrahydrofolate ligase family. | Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Protein involved in catalytic activity. | 0.989 |
| fhs | purL | AMC85_CH03226 | AMC85_CH02392 | Protein involved in formate-tetrahydrofolate ligase activity, ATP binding and folic acid-containing compound biosynthetic process; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylformylglycinamidine synthase 2; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] | 0.830 |
| folA | fhs | AMC85_CH02917 | AMC85_CH03226 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Protein involved in formate-tetrahydrofolate ligase activity, ATP binding and folic acid-containing compound biosynthetic process; Belongs to the formate--tetrahydrofolate ligase family. | 0.920 |
| folA | gcvT | AMC85_CH02917 | AMC85_CH02346 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Protein involved in aminomethyltransferase activity and glycine catabolic process. | 0.905 |
| folA | glyA-1 | AMC85_CH02917 | AMC85_CH01571 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.920 |
| folA | glyA-2 | AMC85_CH02917 | AMC85_CH02084 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Serine hydroxymethyltransferase 2; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.920 |
| folA | metH | AMC85_CH02917 | AMC85_CH03036 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.916 |
| folA | purH | AMC85_CH02917 | AMC85_CH04383 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Protein involved in catalytic activity. | 0.917 |
| folD-1 | fhs | AMC85_CH00743 | AMC85_CH03226 | Bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase FolD 1; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Protein involved in formate-tetrahydrofolate ligase activity, ATP binding and folic acid-containing compound biosynthetic process; Belongs to the formate--tetrahydrofolate ligase family. | 0.997 |
| folD-1 | folD-2 | AMC85_CH00743 | AMC85_CH02085 | Bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase FolD 1; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase FolD 2; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.906 |
| folD-1 | gcvT | AMC85_CH00743 | AMC85_CH02346 | Bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase FolD 1; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Protein involved in aminomethyltransferase activity and glycine catabolic process. | 0.948 |
| folD-1 | glyA-1 | AMC85_CH00743 | AMC85_CH01571 | Bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase FolD 1; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.972 |
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