| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANL61464.1 | gcvH | AMC85_CH04142 | AMC85_CH02347 | Dihydrolipoamide dehydrogenase protein; Protein involved in oxidoreductase activity, flavin adenine dinucleotide binding and oxidation-reduction process. | Glycine-cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.984 |
| ANL61464.1 | gcvP | AMC85_CH04142 | AMC85_CH02348 | Dihydrolipoamide dehydrogenase protein; Protein involved in oxidoreductase activity, flavin adenine dinucleotide binding and oxidation-reduction process. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.955 |
| ANL61464.1 | gcvT | AMC85_CH04142 | AMC85_CH02346 | Dihydrolipoamide dehydrogenase protein; Protein involved in oxidoreductase activity, flavin adenine dinucleotide binding and oxidation-reduction process. | Protein involved in aminomethyltransferase activity and glycine catabolic process. | 0.952 |
| ANL61464.1 | glyA-1 | AMC85_CH04142 | AMC85_CH01571 | Dihydrolipoamide dehydrogenase protein; Protein involved in oxidoreductase activity, flavin adenine dinucleotide binding and oxidation-reduction process. | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.916 |
| ANL61464.1 | glyA-2 | AMC85_CH04142 | AMC85_CH02084 | Dihydrolipoamide dehydrogenase protein; Protein involved in oxidoreductase activity, flavin adenine dinucleotide binding and oxidation-reduction process. | Serine hydroxymethyltransferase 2; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.916 |
| ANL61464.1 | pdhA | AMC85_CH04142 | AMC85_CH02055 | Dihydrolipoamide dehydrogenase protein; Protein involved in oxidoreductase activity, flavin adenine dinucleotide binding and oxidation-reduction process. | Pyruvate dehydrogenase E1 component alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.993 |
| ANL61464.1 | pdhB | AMC85_CH04142 | AMC85_CH02056 | Dihydrolipoamide dehydrogenase protein; Protein involved in oxidoreductase activity, flavin adenine dinucleotide binding and oxidation-reduction process. | Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.999 |
| ANL61464.1 | pdhC | AMC85_CH04142 | AMC85_CH02058 | Dihydrolipoamide dehydrogenase protein; Protein involved in oxidoreductase activity, flavin adenine dinucleotide binding and oxidation-reduction process. | Pyruvate dehydrogenase complex dihydrolipoyllysine-residue acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.985 |
| ANL61464.1 | sucA | AMC85_CH04142 | AMC85_CH04148 | Dihydrolipoamide dehydrogenase protein; Protein involved in oxidoreductase activity, flavin adenine dinucleotide binding and oxidation-reduction process. | 2-oxoglutarate dehydrogenase E1 component; Protein involved in oxoglutarate dehydrogenase (succinyl-transferring) activity, thiamine pyrophosphate binding, tricarboxylic acid cycle and oxidation-reduction process. | 0.996 |
| ANL61464.1 | sucB | AMC85_CH04142 | AMC85_CH04146 | Dihydrolipoamide dehydrogenase protein; Protein involved in oxidoreductase activity, flavin adenine dinucleotide binding and oxidation-reduction process. | Dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). | 0.998 |
| gcvH | ANL61464.1 | AMC85_CH02347 | AMC85_CH04142 | Glycine-cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Dihydrolipoamide dehydrogenase protein; Protein involved in oxidoreductase activity, flavin adenine dinucleotide binding and oxidation-reduction process. | 0.984 |
| gcvH | gcvP | AMC85_CH02347 | AMC85_CH02348 | Glycine-cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
| gcvH | gcvT | AMC85_CH02347 | AMC85_CH02346 | Glycine-cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Protein involved in aminomethyltransferase activity and glycine catabolic process. | 0.999 |
| gcvH | glyA-1 | AMC85_CH02347 | AMC85_CH01571 | Glycine-cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.966 |
| gcvH | glyA-2 | AMC85_CH02347 | AMC85_CH02084 | Glycine-cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Serine hydroxymethyltransferase 2; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.965 |
| gcvH | pdhA | AMC85_CH02347 | AMC85_CH02055 | Glycine-cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Pyruvate dehydrogenase E1 component alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.796 |
| gcvH | pdhB | AMC85_CH02347 | AMC85_CH02056 | Glycine-cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.901 |
| gcvH | pdhC | AMC85_CH02347 | AMC85_CH02058 | Glycine-cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Pyruvate dehydrogenase complex dihydrolipoyllysine-residue acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.845 |
| gcvH | sucA | AMC85_CH02347 | AMC85_CH04148 | Glycine-cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 2-oxoglutarate dehydrogenase E1 component; Protein involved in oxoglutarate dehydrogenase (succinyl-transferring) activity, thiamine pyrophosphate binding, tricarboxylic acid cycle and oxidation-reduction process. | 0.868 |
| gcvH | sucB | AMC85_CH02347 | AMC85_CH04146 | Glycine-cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). | 0.845 |