node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANL60364.1 | ANL61686.1 | AMC85_CH03009 | AMC85_CH04367 | Protein involved in thiamine pyrophosphate binding; Belongs to the TPP enzyme family. | Pyridoxal phosphate-dependent serine/threonine dehydratase protein; Protein involved in catalytic activity, pyridoxal phosphate binding and metabolic process. | 0.937 |
ANL60364.1 | ilvA | AMC85_CH03009 | AMC85_CH01850 | Protein involved in thiamine pyrophosphate binding; Belongs to the TPP enzyme family. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.927 |
ANL60364.1 | ilvC | AMC85_CH03009 | AMC85_CH02860 | Protein involved in thiamine pyrophosphate binding; Belongs to the TPP enzyme family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.987 |
ANL60364.1 | ilvD-1 | AMC85_CH03009 | AMC85_CH01782 | Protein involved in thiamine pyrophosphate binding; Belongs to the TPP enzyme family. | Dihydroxy-acid dehydratase 1; Protein involved in catalytic activity and metabolic process; Belongs to the IlvD/Edd family. | 0.701 |
ANL60364.1 | ilvH | AMC85_CH03009 | AMC85_CH02905 | Protein involved in thiamine pyrophosphate binding; Belongs to the TPP enzyme family. | Acetolactate synthase 3 small subunit; Protein involved in acetolactate synthase activity and branched chain family amino acid biosynthetic process. | 0.998 |
ANL60364.1 | ilvI | AMC85_CH03009 | AMC85_CH02906 | Protein involved in thiamine pyrophosphate binding; Belongs to the TPP enzyme family. | Acetolactate synthase 3 large subunit; Protein involved in magnesium ion binding, acetolactate synthase activity, thiamine pyrophosphate binding, flavin adenine dinucleotide binding and branched chain family amino acid biosynthetic process. | 0.924 |
ANL60364.1 | leuA | AMC85_CH03009 | AMC85_CH03213 | Protein involved in thiamine pyrophosphate binding; Belongs to the TPP enzyme family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.904 |
ANL60364.1 | leuB | AMC85_CH03009 | AMC85_CH04368 | Protein involved in thiamine pyrophosphate binding; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.965 |
ANL60364.1 | leuC | AMC85_CH03009 | AMC85_CH04227 | Protein involved in thiamine pyrophosphate binding; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.647 |
ANL60364.1 | leuD | AMC85_CH03009 | AMC85_CH04366 | Protein involved in thiamine pyrophosphate binding; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.653 |
ANL61686.1 | ANL60364.1 | AMC85_CH04367 | AMC85_CH03009 | Pyridoxal phosphate-dependent serine/threonine dehydratase protein; Protein involved in catalytic activity, pyridoxal phosphate binding and metabolic process. | Protein involved in thiamine pyrophosphate binding; Belongs to the TPP enzyme family. | 0.937 |
ANL61686.1 | ilvA | AMC85_CH04367 | AMC85_CH01850 | Pyridoxal phosphate-dependent serine/threonine dehydratase protein; Protein involved in catalytic activity, pyridoxal phosphate binding and metabolic process. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.925 |
ANL61686.1 | ilvC | AMC85_CH04367 | AMC85_CH02860 | Pyridoxal phosphate-dependent serine/threonine dehydratase protein; Protein involved in catalytic activity, pyridoxal phosphate binding and metabolic process. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.592 |
ANL61686.1 | ilvD-1 | AMC85_CH04367 | AMC85_CH01782 | Pyridoxal phosphate-dependent serine/threonine dehydratase protein; Protein involved in catalytic activity, pyridoxal phosphate binding and metabolic process. | Dihydroxy-acid dehydratase 1; Protein involved in catalytic activity and metabolic process; Belongs to the IlvD/Edd family. | 0.539 |
ANL61686.1 | ilvH | AMC85_CH04367 | AMC85_CH02905 | Pyridoxal phosphate-dependent serine/threonine dehydratase protein; Protein involved in catalytic activity, pyridoxal phosphate binding and metabolic process. | Acetolactate synthase 3 small subunit; Protein involved in acetolactate synthase activity and branched chain family amino acid biosynthetic process. | 0.962 |
ANL61686.1 | ilvI | AMC85_CH04367 | AMC85_CH02906 | Pyridoxal phosphate-dependent serine/threonine dehydratase protein; Protein involved in catalytic activity, pyridoxal phosphate binding and metabolic process. | Acetolactate synthase 3 large subunit; Protein involved in magnesium ion binding, acetolactate synthase activity, thiamine pyrophosphate binding, flavin adenine dinucleotide binding and branched chain family amino acid biosynthetic process. | 0.939 |
ANL61686.1 | leuB | AMC85_CH04367 | AMC85_CH04368 | Pyridoxal phosphate-dependent serine/threonine dehydratase protein; Protein involved in catalytic activity, pyridoxal phosphate binding and metabolic process. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.969 |
ANL61686.1 | leuC | AMC85_CH04367 | AMC85_CH04227 | Pyridoxal phosphate-dependent serine/threonine dehydratase protein; Protein involved in catalytic activity, pyridoxal phosphate binding and metabolic process. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.415 |
ANL61686.1 | leuD | AMC85_CH04367 | AMC85_CH04366 | Pyridoxal phosphate-dependent serine/threonine dehydratase protein; Protein involved in catalytic activity, pyridoxal phosphate binding and metabolic process. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.444 |
ilvA | ANL60364.1 | AMC85_CH01850 | AMC85_CH03009 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Protein involved in thiamine pyrophosphate binding; Belongs to the TPP enzyme family. | 0.927 |