Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
BF93_07625DNA topoisomerase IV subunit A; Derived by automated computational analysis using gene prediction method: Protein Homology. (816 aa)    
Predicted Functional Partners:
gyrB
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
 
 0.996
BF93_07645
DNA topoisomerase IV subunit B; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.988
BF93_07615
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
     0.741
BF93_07610
AP endonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
     0.686
BF93_07620
acyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.661
dnaK
Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 
 0.656
BF93_04960
DNA gyrase subunit A; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 
0.599
BF93_07630
Aldose epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glucose-6-phosphate 1-epimerase family.
       0.594
BF93_05025
Preprotein translocase subunit YidC; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.580
rpoA
DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
  
 0.551
Your Current Organism:
Brachybacterium phenoliresistens
NCBI taxonomy Id: 396014
Other names: B. phenoliresistens, BCRC 17589, Brachybacterium phenoliresistens Chou et al. 2007, Brachybacterium sp. phenol-A, JCM 15157, LMG 23707, LMG:23707, strain phenol-A
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