Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
fniIsopentenyl pyrophosphate isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (370 aa)    
Predicted Functional Partners:
BF93_15935
Phosphomevalonate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.995
BF93_15930
Dihydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.991
BF93_15950
3-hydroxy-3-methylglutaryl-CoA synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.976
BF93_15925
Mevalonate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.972
BF93_15945
hydroxymethylglutaryl-CoA reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
   
 0.939
BF93_09120
Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.918
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
  
 
 0.900
guaB
Inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
   
 
 0.833
BF93_10800
Hypothetical protein; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
 
  
 0.815
BF93_16605
5'-nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.788
Your Current Organism:
Brachybacterium phenoliresistens
NCBI taxonomy Id: 396014
Other names: B. phenoliresistens, BCRC 17589, Brachybacterium phenoliresistens Chou et al. 2007, Brachybacterium sp. phenol-A, JCM 15157, LMG 23707, LMG:23707, strain phenol-A
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