| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KRN58465.1 | acpP | IV45_GL000912 | IV45_GL000131 | NRPS condensation domain-containing protein. | Hypothetical protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. | 0.485 |
| KRN58465.1 | ddl | IV45_GL000912 | IV45_GL001180 | NRPS condensation domain-containing protein. | D-alanine-D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | 0.521 |
| KRN58465.1 | dltA | IV45_GL000912 | IV45_GL001066 | NRPS condensation domain-containing protein. | D-alanine-poly(phosphoribitol) ligase, subunit 1; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to [...] | 0.585 |
| KRN58465.1 | dltC | IV45_GL000912 | IV45_GL001064 | NRPS condensation domain-containing protein. | Hypothetical protein; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. | 0.485 |
| KRN58612.1 | KRN58614.1 | IV45_GL001063 | IV45_GL001065 | D-alanyl transfer protein. | D-alanyl transfer protein; Could be involved in the transport of activated D-alanine through the membrane. | 0.999 |
| KRN58612.1 | KRN59027.1 | IV45_GL001063 | IV45_GL000062 | D-alanyl transfer protein. | Hypothetical protein. | 0.725 |
| KRN58612.1 | acpP | IV45_GL001063 | IV45_GL000131 | D-alanyl transfer protein. | Hypothetical protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. | 0.623 |
| KRN58612.1 | dltA | IV45_GL001063 | IV45_GL001066 | D-alanyl transfer protein. | D-alanine-poly(phosphoribitol) ligase, subunit 1; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to [...] | 0.996 |
| KRN58612.1 | dltC | IV45_GL001063 | IV45_GL001064 | D-alanyl transfer protein. | Hypothetical protein; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. | 0.998 |
| KRN58612.1 | mprF-2 | IV45_GL001063 | IV45_GL000760 | D-alanyl transfer protein. | Hypothetical protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms. | 0.452 |
| KRN58614.1 | KRN58612.1 | IV45_GL001065 | IV45_GL001063 | D-alanyl transfer protein; Could be involved in the transport of activated D-alanine through the membrane. | D-alanyl transfer protein. | 0.999 |
| KRN58614.1 | KRN59027.1 | IV45_GL001065 | IV45_GL000062 | D-alanyl transfer protein; Could be involved in the transport of activated D-alanine through the membrane. | Hypothetical protein. | 0.571 |
| KRN58614.1 | KRN59576.1 | IV45_GL001065 | IV45_GL001325 | D-alanyl transfer protein; Could be involved in the transport of activated D-alanine through the membrane. | Acetaldehyde dehydrogenase (acetylating); In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | 0.465 |
| KRN58614.1 | acpP | IV45_GL001065 | IV45_GL000131 | D-alanyl transfer protein; Could be involved in the transport of activated D-alanine through the membrane. | Hypothetical protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. | 0.882 |
| KRN58614.1 | dltA | IV45_GL001065 | IV45_GL001066 | D-alanyl transfer protein; Could be involved in the transport of activated D-alanine through the membrane. | D-alanine-poly(phosphoribitol) ligase, subunit 1; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to [...] | 0.999 |
| KRN58614.1 | dltC | IV45_GL001065 | IV45_GL001064 | D-alanyl transfer protein; Could be involved in the transport of activated D-alanine through the membrane. | Hypothetical protein; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. | 0.999 |
| KRN58614.1 | mprF-2 | IV45_GL001065 | IV45_GL000760 | D-alanyl transfer protein; Could be involved in the transport of activated D-alanine through the membrane. | Hypothetical protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms. | 0.518 |
| KRN59027.1 | KRN58612.1 | IV45_GL000062 | IV45_GL001063 | Hypothetical protein. | D-alanyl transfer protein. | 0.725 |
| KRN59027.1 | KRN58614.1 | IV45_GL000062 | IV45_GL001065 | Hypothetical protein. | D-alanyl transfer protein; Could be involved in the transport of activated D-alanine through the membrane. | 0.571 |
| KRN59027.1 | dltA | IV45_GL000062 | IV45_GL001066 | Hypothetical protein. | D-alanine-poly(phosphoribitol) ligase, subunit 1; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to [...] | 0.589 |
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