| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KRN58863.1 | KRN59249.1 | IV45_GL000490 | IV45_GL001396 | TPR repeat-containing protein. | Protein tyrosine phosphatase; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. | 0.817 |
| KRN58863.1 | aspS | IV45_GL000490 | IV45_GL000443 | TPR repeat-containing protein. | aspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. | 0.648 |
| KRN58863.1 | dnaJ | IV45_GL000490 | IV45_GL000405 | TPR repeat-containing protein. | Chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and [...] | 0.608 |
| KRN58863.1 | ftsH | IV45_GL000490 | IV45_GL001380 | TPR repeat-containing protein. | ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.614 |
| KRN58863.1 | grpE | IV45_GL000490 | IV45_GL000403 | TPR repeat-containing protein. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.460 |
| KRN58863.1 | htpX | IV45_GL000490 | IV45_GL001394 | TPR repeat-containing protein. | Heat shock protein HtpX; Belongs to the peptidase M48B family. | 0.457 |
| KRN59248.1 | KRN59249.1 | IV45_GL001395 | IV45_GL001396 | LemA family protein. | Protein tyrosine phosphatase; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. | 0.525 |
| KRN59248.1 | htpX | IV45_GL001395 | IV45_GL001394 | LemA family protein. | Heat shock protein HtpX; Belongs to the peptidase M48B family. | 0.829 |
| KRN59248.1 | murF | IV45_GL001395 | IV45_GL001393 | LemA family protein. | UDP-MurNAc-pentapeptide synthetase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | 0.463 |
| KRN59249.1 | KRN58863.1 | IV45_GL001396 | IV45_GL000490 | Protein tyrosine phosphatase; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. | TPR repeat-containing protein. | 0.817 |
| KRN59249.1 | KRN59248.1 | IV45_GL001396 | IV45_GL001395 | Protein tyrosine phosphatase; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. | LemA family protein. | 0.525 |
| KRN59249.1 | htpX | IV45_GL001396 | IV45_GL001394 | Protein tyrosine phosphatase; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. | Heat shock protein HtpX; Belongs to the peptidase M48B family. | 0.511 |
| aspS | KRN58863.1 | IV45_GL000443 | IV45_GL000490 | aspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. | TPR repeat-containing protein. | 0.648 |
| aspS | hisS | IV45_GL000443 | IV45_GL000442 | aspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. | histidyl-tRNA synthetase. | 0.990 |
| aspS | htpX | IV45_GL000443 | IV45_GL001394 | aspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. | Heat shock protein HtpX; Belongs to the peptidase M48B family. | 0.518 |
| dnaJ | KRN58863.1 | IV45_GL000405 | IV45_GL000490 | Chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and [...] | TPR repeat-containing protein. | 0.608 |
| dnaJ | ftsH | IV45_GL000405 | IV45_GL001380 | Chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and [...] | ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.704 |
| dnaJ | grpE | IV45_GL000405 | IV45_GL000403 | Chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and [...] | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.997 |
| dnaJ | htpX | IV45_GL000405 | IV45_GL001394 | Chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and [...] | Heat shock protein HtpX; Belongs to the peptidase M48B family. | 0.685 |
| dnaJ | secY | IV45_GL000405 | IV45_GL000687 | Chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and [...] | Preprotein translocase, SecY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.634 |
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