STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CIHG_01662Tyrosyl-DNA phosphodiesterase 1. (620 aa)    
Predicted Functional Partners:
CIHG_09549
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]
    
 
 0.938
CIHG_09387
Mei-9 protein.
   
 
 0.779
CIHG_02585
Ku70.
     
 0.762
CIHG_05885
Ku80.
    
 0.731
CIHG_02236
DNA-(Apurinic or apyrimidinic site) lyase 2.
   
 
 0.718
CIHG_00529
Crossover junction endonuclease mus-81.
   
 
 0.699
CIHG_05724
DNA ligase.
   
 
 0.684
CIHG_03498
Conserved eukaryotic protein.
    
 
 0.672
CIHG_06575
DNA kinase/phosphatase Pnk1.
    
 
 0.647
CIHG_03961
Ubiquitin/metalloprotease fusion protein.
    
 
 0.626
Your Current Organism:
Coccidioides immitis H5384
NCBI taxonomy Id: 396776
Other names: C. immitis H538.4, Coccidioides immitis H538.4
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.