node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ORB25911.1 | ORB25912.1 | BST36_04745 | BST36_04750 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.911 |
ORB25911.1 | ORB25914.1 | BST36_04745 | BST36_04760 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dienelactone hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.641 |
ORB25911.1 | ORB25915.1 | BST36_04745 | BST36_04765 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | CoA ester lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the HpcH/HpaI aldolase family. | 0.467 |
ORB25911.1 | dapA | BST36_04745 | BST36_04725 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | 0.470 |
ORB25911.1 | rnj | BST36_04745 | BST36_04720 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Ribonuclease J; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. | 0.506 |
ORB25911.1 | thyA | BST36_04745 | BST36_04755 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.888 |
ORB25911.1 | thyX | BST36_04745 | BST36_04730 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.467 |
ORB25912.1 | ORB25911.1 | BST36_04750 | BST36_04745 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.911 |
ORB25912.1 | ORB25914.1 | BST36_04750 | BST36_04760 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Dienelactone hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.742 |
ORB25912.1 | ORB25915.1 | BST36_04750 | BST36_04765 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | CoA ester lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the HpcH/HpaI aldolase family. | 0.483 |
ORB25912.1 | thyA | BST36_04750 | BST36_04755 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.999 |
ORB25912.1 | thyX | BST36_04750 | BST36_04730 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.985 |
ORB25914.1 | ORB25911.1 | BST36_04760 | BST36_04745 | Dienelactone hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.641 |
ORB25914.1 | ORB25912.1 | BST36_04760 | BST36_04750 | Dienelactone hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.742 |
ORB25914.1 | ORB25915.1 | BST36_04760 | BST36_04765 | Dienelactone hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | CoA ester lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the HpcH/HpaI aldolase family. | 0.642 |
ORB25914.1 | thyA | BST36_04760 | BST36_04755 | Dienelactone hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.644 |
ORB25915.1 | ORB25911.1 | BST36_04765 | BST36_04745 | CoA ester lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the HpcH/HpaI aldolase family. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.467 |
ORB25915.1 | ORB25912.1 | BST36_04765 | BST36_04750 | CoA ester lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the HpcH/HpaI aldolase family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.483 |
ORB25915.1 | ORB25914.1 | BST36_04765 | BST36_04760 | CoA ester lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the HpcH/HpaI aldolase family. | Dienelactone hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.642 |
ORB25915.1 | thyA | BST36_04765 | BST36_04755 | CoA ester lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the HpcH/HpaI aldolase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.486 |