STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ORB39539.1Dihydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (229 aa)    
Predicted Functional Partners:
ORB41828.1
Dihydrofolate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
  0.894
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
    
  0.871
ORB39638.1
RNA polymerase subunit sigma; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
  
  
 0.807
gcvP-2
Glycine dehydrogenase (aminomethyl-transferring); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
    
  0.786
ORB39570.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
  
 0.738
ORB42427.1
Peptidase S1; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
    0.713
ORB34123.1
ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.700
ORB34122.1
ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.697
ORB34121.1
Zinc ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.642
ORB34168.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.642
Your Current Organism:
Mycolicibacterium porcinum
NCBI taxonomy Id: 39693
Other names: ATCC 33776, CCUG 37674, CIP 105392, DSM 44242, JCM 6378, M. porcinum, Mycobacterium porcinum, strain E10241-1
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