| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ORB34546.1 | ORB39595.1 | BST41_30570 | BST41_17500 | LLM class F420-dependent oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.426 |
| ORB34546.1 | ORB39597.1 | BST41_30570 | BST41_17510 | LLM class F420-dependent oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dienelactone hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.580 |
| ORB34546.1 | thyA | BST41_30570 | BST41_17505 | LLM class F420-dependent oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.473 |
| ORB36327.1 | ORB38280.1 | BST41_25945 | BST41_21015 | Dienelactone hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Carboxymethylenebutenolidase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.909 |
| ORB36327.1 | ORB39597.1 | BST41_25945 | BST41_17510 | Dienelactone hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dienelactone hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.953 |
| ORB36327.1 | ORB43508.1 | BST41_25945 | BST41_05125 | Dienelactone hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 3-hydroxyacyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.531 |
| ORB36327.1 | ORB43522.1 | BST41_25945 | BST41_05195 | Dienelactone hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.759 |
| ORB36327.1 | ORB44938.1 | BST41_25945 | BST41_03395 | Dienelactone hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Mandelate racemase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.760 |
| ORB36327.1 | ORB44939.1 | BST41_25945 | BST41_03400 | Dienelactone hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Catechol 1,2-dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.879 |
| ORB38280.1 | ORB36327.1 | BST41_21015 | BST41_25945 | Carboxymethylenebutenolidase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dienelactone hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.909 |
| ORB38280.1 | ORB39597.1 | BST41_21015 | BST41_17510 | Carboxymethylenebutenolidase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dienelactone hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.907 |
| ORB38280.1 | ORB43508.1 | BST41_21015 | BST41_05125 | Carboxymethylenebutenolidase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 3-hydroxyacyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.531 |
| ORB38280.1 | ORB43522.1 | BST41_21015 | BST41_05195 | Carboxymethylenebutenolidase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.719 |
| ORB38280.1 | ORB44938.1 | BST41_21015 | BST41_03395 | Carboxymethylenebutenolidase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Mandelate racemase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.760 |
| ORB38280.1 | ORB44939.1 | BST41_21015 | BST41_03400 | Carboxymethylenebutenolidase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Catechol 1,2-dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.848 |
| ORB39595.1 | ORB34546.1 | BST41_17500 | BST41_30570 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | LLM class F420-dependent oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.426 |
| ORB39595.1 | ORB39597.1 | BST41_17500 | BST41_17510 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Dienelactone hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.799 |
| ORB39595.1 | ORB39598.1 | BST41_17500 | BST41_17515 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | CoA ester lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the HpcH/HpaI aldolase family. | 0.535 |
| ORB39595.1 | thyA | BST41_17500 | BST41_17505 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.999 |
| ORB39597.1 | ORB34546.1 | BST41_17510 | BST41_30570 | Dienelactone hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. | LLM class F420-dependent oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.580 |