murI protein (Lachnospiraceae bacterium A2) - STRING interaction network

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Score

murI

Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (275 aa)

Predicted Functional Partners:

murD

0.990

C810_04367

0.943

C810_00336

0.897

C810_01003

0.854

guaB

0.817

guaA

0.792

C810_01765

0.789

C810_03323

0.747

murC

0.723

murF

0.696

Your Current Organism:

Lachnospiraceae bacterium A2

NCBI taxonomy Id: 397290
Other names: L. bacterium A2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C810_00336	C810_01765	C810_00336	C810_01765	Glutamate dehydrogenase (NADP+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	Phosphoribosylformylglycinamidine synthase.	0.849
C810_00336	guaA	C810_00336	C810_00804	Glutamate dehydrogenase (NADP+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.	0.537
C810_00336	guaB	C810_00336	C810_04425	Glutamate dehydrogenase (NADP+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.528
C810_00336	murI	C810_00336	C810_01002	Glutamate dehydrogenase (NADP+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis.	0.897
C810_01003	murI	C810_01003	C810_01002	Hypothetical protein.	Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis.	0.854
C810_01765	C810_00336	C810_01765	C810_00336	Phosphoribosylformylglycinamidine synthase.	Glutamate dehydrogenase (NADP+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	0.849
C810_01765	C810_03323	C810_01765	C810_03323	Phosphoribosylformylglycinamidine synthase.	Hypothetical protein.	0.747
C810_01765	C810_04367	C810_01765	C810_04367	Phosphoribosylformylglycinamidine synthase.	RdgB/HAM1 family non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	0.495
C810_01765	guaA	C810_01765	C810_00804	Phosphoribosylformylglycinamidine synthase.	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.	0.999
C810_01765	guaB	C810_01765	C810_04425	Phosphoribosylformylglycinamidine synthase.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.965
C810_01765	murD	C810_01765	C810_02222	Phosphoribosylformylglycinamidine synthase.	UDP-N-acetylmuramoylalanine-D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family.	0.785
C810_01765	murI	C810_01765	C810_01002	Phosphoribosylformylglycinamidine synthase.	Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis.	0.789
C810_03323	C810_01765	C810_03323	C810_01765	Hypothetical protein.	Phosphoribosylformylglycinamidine synthase.	0.747
C810_03323	murC	C810_03323	C810_00705	Hypothetical protein.	UDP-N-acetylmuramate-alanine ligase; Cell wall formation; Belongs to the MurCDEF family.	0.747
C810_03323	murI	C810_03323	C810_01002	Hypothetical protein.	Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis.	0.747
C810_04367	C810_01765	C810_04367	C810_01765	RdgB/HAM1 family non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	Phosphoribosylformylglycinamidine synthase.	0.495
C810_04367	guaA	C810_04367	C810_00804	RdgB/HAM1 family non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.	0.978
C810_04367	guaB	C810_04367	C810_04425	RdgB/HAM1 family non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.	0.936
C810_04367	murD	C810_04367	C810_02222	RdgB/HAM1 family non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	UDP-N-acetylmuramoylalanine-D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family.	0.661
C810_04367	murI	C810_04367	C810_01002	RdgB/HAM1 family non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis.	0.943