| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C810_01765 | C810_04978 | C810_01765 | C810_04978 | Phosphoribosylformylglycinamidine synthase. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.999 |
| C810_01765 | fhs | C810_01765 | C810_02960 | Phosphoribosylformylglycinamidine synthase. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.985 |
| C810_01765 | folD | C810_01765 | C810_02959 | Phosphoribosylformylglycinamidine synthase. | FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.904 |
| C810_01765 | glyA | C810_01765 | C810_01758 | Phosphoribosylformylglycinamidine synthase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.997 |
| C810_01765 | purD | C810_01765 | C810_04254 | Phosphoribosylformylglycinamidine synthase. | Phosphoribosylamine-glycine ligase; Belongs to the GARS family. | 0.999 |
| C810_01765 | purN | C810_01765 | C810_04255 | Phosphoribosylformylglycinamidine synthase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.999 |
| C810_02058 | C810_02059 | C810_02058 | C810_02059 | L-serine dehydratase, iron-sulfur-dependent, beta subunit. | L-serine dehydratase, iron-sulfur-dependent, alpha subunit. | 0.999 |
| C810_02058 | glyA | C810_02058 | C810_01758 | L-serine dehydratase, iron-sulfur-dependent, beta subunit. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.967 |
| C810_02059 | C810_02058 | C810_02059 | C810_02058 | L-serine dehydratase, iron-sulfur-dependent, alpha subunit. | L-serine dehydratase, iron-sulfur-dependent, beta subunit. | 0.999 |
| C810_02059 | glyA | C810_02059 | C810_01758 | L-serine dehydratase, iron-sulfur-dependent, alpha subunit. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.963 |
| C810_02791 | C810_04978 | C810_02791 | C810_04978 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.665 |
| C810_02791 | fhs | C810_02791 | C810_02960 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.838 |
| C810_02791 | folD | C810_02791 | C810_02959 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.948 |
| C810_02791 | glyA | C810_02791 | C810_01758 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.952 |
| C810_02791 | purN | C810_02791 | C810_04255 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.667 |
| C810_04978 | C810_01765 | C810_04978 | C810_01765 | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | Phosphoribosylformylglycinamidine synthase. | 0.999 |
| C810_04978 | C810_02791 | C810_04978 | C810_02791 | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.665 |
| C810_04978 | fhs | C810_04978 | C810_02960 | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.985 |
| C810_04978 | folD | C810_04978 | C810_02959 | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.973 |
| C810_04978 | glyA | C810_04978 | C810_01758 | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.996 |