glyA protein (Lachnospiraceae bacterium A2) - STRING interaction network

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Your Current Organism:

Lachnospiraceae bacterium A2

NCBI taxonomy Id: 397290
Other names: L. bacterium A2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C810_01765	C810_04978	C810_01765	C810_04978	Phosphoribosylformylglycinamidine synthase.	Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase.	0.999
C810_01765	fhs	C810_01765	C810_02960	Phosphoribosylformylglycinamidine synthase.	Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family.	0.943
C810_01765	folD	C810_01765	C810_02959	Phosphoribosylformylglycinamidine synthase.	FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	0.915
C810_01765	glyA	C810_01765	C810_01758	Phosphoribosylformylglycinamidine synthase.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.975
C810_01765	purN	C810_01765	C810_04255	Phosphoribosylformylglycinamidine synthase.	Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.	0.999
C810_02058	C810_02059	C810_02058	C810_02059	L-serine dehydratase, iron-sulfur-dependent, beta subunit.	L-serine dehydratase, iron-sulfur-dependent, alpha subunit.	0.999
C810_02058	glyA	C810_02058	C810_01758	L-serine dehydratase, iron-sulfur-dependent, beta subunit.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.967
C810_02059	C810_02058	C810_02059	C810_02058	L-serine dehydratase, iron-sulfur-dependent, alpha subunit.	L-serine dehydratase, iron-sulfur-dependent, beta subunit.	0.999
C810_02059	glyA	C810_02059	C810_01758	L-serine dehydratase, iron-sulfur-dependent, alpha subunit.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.967
C810_02789	C810_04978	C810_02789	C810_04978	methylmalonyl-CoA mutase domain-containing protein.	Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase.	0.899
C810_02789	C810_05011	C810_02789	C810_05011	methylmalonyl-CoA mutase domain-containing protein.	Ribose 5-phosphate isomerase B.	0.860
C810_02789	fhs	C810_02789	C810_02960	methylmalonyl-CoA mutase domain-containing protein.	Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family.	0.954
C810_02789	folD	C810_02789	C810_02959	methylmalonyl-CoA mutase domain-containing protein.	FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	0.877
C810_02789	glyA	C810_02789	C810_01758	methylmalonyl-CoA mutase domain-containing protein.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.934
C810_02789	purN	C810_02789	C810_04255	methylmalonyl-CoA mutase domain-containing protein.	Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.	0.898
C810_04184	glyA	C810_04184	C810_01758	Hypothetical protein.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.942
C810_04978	C810_01765	C810_04978	C810_01765	Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase.	Phosphoribosylformylglycinamidine synthase.	0.999
C810_04978	C810_02789	C810_04978	C810_02789	Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase.	methylmalonyl-CoA mutase domain-containing protein.	0.899
C810_04978	C810_05011	C810_04978	C810_05011	Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase.	Ribose 5-phosphate isomerase B.	0.495
C810_04978	fhs	C810_04978	C810_02960	Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase.	Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family.	0.985