| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C810_00248 | C810_01288 | C810_00248 | C810_01288 | D,D-heptose 1,7-bisphosphate phosphatase. | Hypothetical protein. | 0.621 |
| C810_00248 | C810_04420 | C810_00248 | C810_04420 | D,D-heptose 1,7-bisphosphate phosphatase. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Belongs to the HisA/HisF family. | 0.758 |
| C810_00248 | hisC | C810_00248 | C810_01755 | D,D-heptose 1,7-bisphosphate phosphatase. | Histidinol-phosphate transaminase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.820 |
| C810_00248 | hisD | C810_00248 | C810_02744 | D,D-heptose 1,7-bisphosphate phosphatase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.924 |
| C810_00248 | hisF | C810_00248 | C810_01912 | D,D-heptose 1,7-bisphosphate phosphatase. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.917 |
| C810_00248 | hisG | C810_00248 | C810_02745 | D,D-heptose 1,7-bisphosphate phosphatase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.751 |
| C810_00248 | hisH | C810_00248 | C810_01911 | D,D-heptose 1,7-bisphosphate phosphatase. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.917 |
| C810_00248 | hisI | C810_00248 | C810_02742 | D,D-heptose 1,7-bisphosphate phosphatase. | phosphoribosyl-ATP diphosphatase; In the C-terminal section; belongs to the PRA-PH family. | 0.964 |
| C810_01288 | C810_00248 | C810_01288 | C810_00248 | Hypothetical protein. | D,D-heptose 1,7-bisphosphate phosphatase. | 0.621 |
| C810_01288 | C810_04420 | C810_01288 | C810_04420 | Hypothetical protein. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Belongs to the HisA/HisF family. | 0.917 |
| C810_01288 | hisB | C810_01288 | C810_02743 | Hypothetical protein. | Imidazoleglycerol-phosphate dehydratase. | 0.811 |
| C810_01288 | hisC | C810_01288 | C810_01755 | Hypothetical protein. | Histidinol-phosphate transaminase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.681 |
| C810_01288 | hisD | C810_01288 | C810_02744 | Hypothetical protein. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.842 |
| C810_01288 | hisF | C810_01288 | C810_01912 | Hypothetical protein. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.923 |
| C810_01288 | hisG | C810_01288 | C810_02745 | Hypothetical protein. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.630 |
| C810_01288 | hisH | C810_01288 | C810_01911 | Hypothetical protein. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.810 |
| C810_01288 | hisI | C810_01288 | C810_02742 | Hypothetical protein. | phosphoribosyl-ATP diphosphatase; In the C-terminal section; belongs to the PRA-PH family. | 0.976 |
| C810_01288 | hisZ | C810_01288 | C810_02746 | Hypothetical protein. | ATP phosphoribosyltransferase, regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.730 |
| C810_04420 | C810_00248 | C810_04420 | C810_00248 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Belongs to the HisA/HisF family. | D,D-heptose 1,7-bisphosphate phosphatase. | 0.758 |
| C810_04420 | C810_01288 | C810_04420 | C810_01288 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Belongs to the HisA/HisF family. | Hypothetical protein. | 0.917 |
