Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (313 aa)    
Predicted Functional Partners:
KXB88183.1
Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
 
 0.995
KXB88182.1
Chlorite O(2)-lyase; KEGG: sax:USA300HOU_0580 6.7e-52 putative heme peroxidase K09162; Psort location: Cytoplasmic, score: 8.96.
 
 
 0.993
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
  
 0.987
hemC
Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
  
 0.669
CysG_1
KEGG: vpr:Vpar_1424 1.5e-253 uroporphyrin-III C-methyltransferase; K13542 uroporphyrinogen III methyltransferase / synthase; Psort location: Cytoplasmic, score: 9.97.
  
  
 0.595
lon
Endopeptidase La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
     
  0.593
KXB88186.1
Hypothetical protein; KEGG: lru:HMPREF0538_20279 2.1e-18 ppx3; exopolyphosphatase; Psort location: Cytoplasmic, score: 8.96.
 
     0.587
HemB
Porphobilinogen synthase; KEGG: vpr:Vpar_1423 2.8e-156 delta-aminolevulinic acid dehydratase; K01698 porphobilinogen synthase; Psort location: Cytoplasmic, score: 9.97; Belongs to the ALAD family.
 
  
 0.557
KXB88187.1
Ser/Thr phosphatase family protein; KEGG: bsr:I33_1120 1.8e-49 YhaO; Psort location: Cytoplasmic, score: 8.96.
     
 0.541
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
  
 0.500
Your Current Organism:
Veillonella dispar
NCBI taxonomy Id: 39778
Other names: ATCC 17748, DSM 20735, NCTC 11831, V. dispar, Veillonella alcalescens subsp. dispar
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