Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
IlvB_1KEGG: ccb:Clocel_4174 1.8e-186 acetolactate synthase large subunit; K01652 acetolactate synthase I/II/III large subunit; Psort location: Cytoplasmic, score: 9.97. (584 aa)    
Predicted Functional Partners:
IlvH_1
Acetolactate synthase, small subunit; KEGG: glo:Glov_2502 1.0e-25 ilvH; acetolactate synthase 3 regulatory subunit; K01653 acetolactate synthase I/III small subunit; Psort location: Cytoplasmic, score: 9.97.
 
 0.998
ilvN
KEGG: vpr:Vpar_1438 2.3e-74 acetolactate synthase small subunit; K01653 acetolactate synthase I/III small subunit; Psort location: Cytoplasmic, score: 9.97.
 
 0.993
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.989
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 
 0.963
TdcB
KEGG: vpr:Vpar_1440 3.0e-200 threonine dehydratase; K01754 threonine dehydratase; Psort location: Cytoplasmic, score: 9.97.
 
 0.960
PorA_1
KEGG: vpr:Vpar_1390 0. pyruvate ferredoxin/flavodoxin oxidoreductase; K03737 putative pyruvate-flavodoxin oxidoreductase; Psort location: Cytoplasmic, score: 8.96.
  
 
 0.955
PorA_2
2-oxoacid:acceptor oxidoreductase, alpha subunit; KEGG: vpr:Vpar_1461 0. pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein; K00174 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Psort location: Cytoplasmic, score: 8.96.
  
 
 0.933
ilvD
KEGG: vpr:Vpar_1441 7.9e-287 dihydroxy-acid dehydratase; K01687 dihydroxy-acid dehydratase; Psort location: Cytoplasmic, score: 9.97; Belongs to the IlvD/Edd family.
 
 0.921
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
 
 
 0.920
PflB_2
KEGG: vpr:Vpar_0255 0. formate acetyltransferase; K00656 formate C-acetyltransferase; Psort location: Cytoplasmic, score: 9.97.
     
 0.906
Your Current Organism:
Veillonella dispar
NCBI taxonomy Id: 39778
Other names: ATCC 17748, DSM 20735, NCTC 11831, V. dispar, Veillonella alcalescens subsp. dispar
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