Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
RibD_1Cytidine and deoxycytidylate deaminase zinc-binding region; KEGG: vpr:Vpar_0963 1.8e-81 CMP/dCMP deaminase zinc-binding protein; K01493 dCMP deaminase. (159 aa)    
Predicted Functional Partners:
Dut
Putative dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
  
 0.930
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.924
tmk
dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
    
 0.916
YfbR
HD domain protein; KEGG: vpr:Vpar_0282 1.1e-83 metal dependent phosphohydrolase; K08722 5'-nucleotidase; Psort location: Cytoplasmic, score: 8.96.
     
  0.900
surE
SurE-like protein; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
     
  0.900
cmk
Cytidylate kinase; KEGG: vpr:Vpar_0829 3.8e-97 cytidylate kinase; K00945 cytidylate kinase; Psort location: Cytoplasmic, score: 9.97.
    
  0.900
KXB84419.1
KEGG: sth:STH1865 4.2e-82 Xaa-Pro dipeptidase; K01271 Xaa-Pro dipeptidase; Psort location: Cytoplasmic, score: 9.97; Belongs to the peptidase M24B family.
  
  
 0.654
leuS
leucine--tRNA ligase; KEGG: vpr:Vpar_0964 0. leucyl-tRNA synthetase; K01869 leucyl-tRNA synthetase; Psort location: Cytoplasmic, score: 9.97; Belongs to the class-I aminoacyl-tRNA synthetase family.
   
   0.642
KXB86339.1
comEA protein; KEGG: hor:Hore_06940 2.9e-10 glycogen/starch synthase K00703; Psort location: CytoplasmicMembrane, score: 9.82.
  
  
 0.587
YdhD
Hypothetical protein; KEGG: bmq:BMQ_1498 1.8e-42 glycosyl hydrolase family 18 protein.
 
     0.534
Your Current Organism:
Veillonella dispar
NCBI taxonomy Id: 39778
Other names: ATCC 17748, DSM 20735, NCTC 11831, V. dispar, Veillonella alcalescens subsp. dispar
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