Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (364 aa)    
Predicted Functional Partners:
aroA
3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
 
 
 0.998
PheA
Prephenate dehydratase; KEGG: vpr:Vpar_1614 7.3e-197 chorismate mutase; K14170 chorismate mutase / prephenate dehydratase; Psort location: Cytoplasmic, score: 9.97.
 
 
 0.998
aroK-2
Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family.
  
 0.995
aroB
3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
 
  
 0.992
TrpE
KEGG: vpr:Vpar_0158 1.9e-253 chorismate binding-like protein; K01657 anthranilate synthase component I; Psort location: Cytoplasmic, score: 9.97.
 
 
 0.980
aroK-3
Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family.
 
  
 0.954
PabA
KEGG: vpr:Vpar_0159 7.1e-96 glutamine amidotransferase; K01658 anthranilate synthase component II; Psort location: Cytoplasmic, score: 9.97.
 
 
 0.945
AroF
3-deoxy-7-phosphoheptulonate synthase; KEGG: vpr:Vpar_1610 6.0e-170 phospho-2-dehydro-3-deoxyheptonate aldolase; K03856 3-deoxy-7-phosphoheptulonate synthase; Psort location: Cytoplasmic, score: 9.97.
 
  
 0.926
DhbC
KEGG: vpr:Vpar_0373 9.5e-188 isochorismate synthase; K02552 menaquinone-specific isochorismate synthase; Psort location: Cytoplasmic, score: 9.26.
 
  
 0.900
KXB84434.1
ACT domain protein; KEGG: vpr:Vpar_0898 9.2e-71 amino acid-binding ACT protein; K06209 chorismate mutase; Psort location: Cytoplasmic, score: 8.96; Belongs to the UPF0735 family.
     
  0.900
Your Current Organism:
Veillonella dispar
NCBI taxonomy Id: 39778
Other names: ATCC 17748, DSM 20735, NCTC 11831, V. dispar, Veillonella alcalescens subsp. dispar
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.