Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DfrA | Fgs | HMPREF1867_01182 | HMPREF1867_00466 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Protein FolC; KEGG: vpr:Vpar_1251 6.1e-209 bifunctional folylpolyglutamate synthase/dihydrofolate synthase; K11754 dihydrofolate synthase / folylpolyglutamate synthase; Psort location: Cytoplasmic, score: 9.97. | 0.924 |
| DfrA | glyA | HMPREF1867_01182 | HMPREF1867_00769 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.932 |
| DfrA | thyA | HMPREF1867_01182 | HMPREF1867_01183 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.997 |
| Dut | NrdA | HMPREF1867_01445 | HMPREF1867_01078 | Putative dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.721 |
| Dut | RibD_1 | HMPREF1867_01445 | HMPREF1867_00904 | Putative dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Cytidine and deoxycytidylate deaminase zinc-binding region; KEGG: vpr:Vpar_0963 1.8e-81 CMP/dCMP deaminase zinc-binding protein; K01493 dCMP deaminase. | 0.939 |
| Dut | YfbR | HMPREF1867_01445 | HMPREF1867_00300 | Putative dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | HD domain protein; KEGG: vpr:Vpar_0282 1.1e-83 metal dependent phosphohydrolase; K08722 5'-nucleotidase; Psort location: Cytoplasmic, score: 8.96. | 0.900 |
| Dut | surE | HMPREF1867_01445 | HMPREF1867_00816 | Putative dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | SurE-like protein; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |
| Dut | thyA | HMPREF1867_01445 | HMPREF1867_01183 | Putative dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.963 |
| Fgs | DfrA | HMPREF1867_00466 | HMPREF1867_01182 | Protein FolC; KEGG: vpr:Vpar_1251 6.1e-209 bifunctional folylpolyglutamate synthase/dihydrofolate synthase; K11754 dihydrofolate synthase / folylpolyglutamate synthase; Psort location: Cytoplasmic, score: 9.97. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.924 |
| Fgs | folD | HMPREF1867_00466 | HMPREF1867_00960 | Protein FolC; KEGG: vpr:Vpar_1251 6.1e-209 bifunctional folylpolyglutamate synthase/dihydrofolate synthase; K11754 dihydrofolate synthase / folylpolyglutamate synthase; Psort location: Cytoplasmic, score: 9.97. | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.508 |
| Fgs | glyA | HMPREF1867_00466 | HMPREF1867_00769 | Protein FolC; KEGG: vpr:Vpar_1251 6.1e-209 bifunctional folylpolyglutamate synthase/dihydrofolate synthase; K11754 dihydrofolate synthase / folylpolyglutamate synthase; Psort location: Cytoplasmic, score: 9.97. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.686 |
| Fgs | thyA | HMPREF1867_00466 | HMPREF1867_01183 | Protein FolC; KEGG: vpr:Vpar_1251 6.1e-209 bifunctional folylpolyglutamate synthase/dihydrofolate synthase; K11754 dihydrofolate synthase / folylpolyglutamate synthase; Psort location: Cytoplasmic, score: 9.97. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.849 |
| MetF | folD | HMPREF1867_01655 | HMPREF1867_00960 | Homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase domain protein; KEGG: mas:Mahau_0258 1.6e-66 homocysteine S-methyltransferase; K00547 homocysteine S-methyltransferase; Psort location: Cytoplasmic, score: 8.96; Belongs to the methylenetetrahydrofolate reductase family. | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.930 |
| MetF | glyA | HMPREF1867_01655 | HMPREF1867_00769 | Homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase domain protein; KEGG: mas:Mahau_0258 1.6e-66 homocysteine S-methyltransferase; K00547 homocysteine S-methyltransferase; Psort location: Cytoplasmic, score: 8.96; Belongs to the methylenetetrahydrofolate reductase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.944 |
| MetF | thyA | HMPREF1867_01655 | HMPREF1867_01183 | Homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase domain protein; KEGG: mas:Mahau_0258 1.6e-66 homocysteine S-methyltransferase; K00547 homocysteine S-methyltransferase; Psort location: Cytoplasmic, score: 8.96; Belongs to the methylenetetrahydrofolate reductase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.924 |
| NrdA | Dut | HMPREF1867_01078 | HMPREF1867_01445 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Putative dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.721 |
| NrdA | thyA | HMPREF1867_01078 | HMPREF1867_01183 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.753 |
| RibD_1 | Dut | HMPREF1867_00904 | HMPREF1867_01445 | Cytidine and deoxycytidylate deaminase zinc-binding region; KEGG: vpr:Vpar_0963 1.8e-81 CMP/dCMP deaminase zinc-binding protein; K01493 dCMP deaminase. | Putative dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.939 |
| RibD_1 | YfbR | HMPREF1867_00904 | HMPREF1867_00300 | Cytidine and deoxycytidylate deaminase zinc-binding region; KEGG: vpr:Vpar_0963 1.8e-81 CMP/dCMP deaminase zinc-binding protein; K01493 dCMP deaminase. | HD domain protein; KEGG: vpr:Vpar_0282 1.1e-83 metal dependent phosphohydrolase; K08722 5'-nucleotidase; Psort location: Cytoplasmic, score: 8.96. | 0.900 |
| RibD_1 | surE | HMPREF1867_00904 | HMPREF1867_00816 | Cytidine and deoxycytidylate deaminase zinc-binding region; KEGG: vpr:Vpar_0963 1.8e-81 CMP/dCMP deaminase zinc-binding protein; K01493 dCMP deaminase. | SurE-like protein; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |
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