Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
IspD1KEGG: vpr:Vpar_0675 1.6e-112 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; K00991 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Psort location: Cytoplasmic, score: 9.97; Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. (240 aa)    
Predicted Functional Partners:
dxr
1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family.
 
 
 0.917
ispE
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
 
  
 0.913
RfbB_2
NAD dependent epimerase/dehydratase family protein; KEGG: sgo:SGO_2016 2.0e-68 nucleotide sugar dehydratase K01710; Psort location: Cytoplasmic, score: 9.97.
 
   
 0.856
KXB83890.1
LICD family protein; KEGG: snc:HMPREF0837_11182 9.7e-60 lipopolysaccharide cholinephosphotransferase; Psort location: Cytoplasmic, score: 8.96.
 
   
 0.839
ispDF
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF).
 
  
0.823
ispG
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family.
 
   
 0.813
TagE
Glycosyltransferase, group 1 family protein; KEGG: npu:Npun_F1369 2.3e-42 group 1 glycosyl transferase; Psort location: Cytoplasmic, score: 9.97.
       0.782
WcaJ_2
Bacterial sugar transferase; KEGG: spd:SPD_1620 1.2e-59 glycosyl transferase family protein K00754; Psort location: CytoplasmicMembrane, score: 10.00.
  
    0.763
ArnB
DegT/DnrJ/EryC1/StrS aminotransferase family protein; KEGG: bce:BC5273 2.6e-137 UDP-bacillosamine synthetase; Psort location: Cytoplasmic, score: 9.97; Belongs to the DegT/DnrJ/EryC1 family.
       0.719
KXB83883.1
Polysaccharide biosynthesis protein; KEGG: cco:CCC13826_0528 2.9e-06 cytosol aminopeptidase; Psort location: CytoplasmicMembrane, score: 10.00.
  
    0.634
Your Current Organism:
Veillonella dispar
NCBI taxonomy Id: 39778
Other names: ATCC 17748, DSM 20735, NCTC 11831, V. dispar, Veillonella alcalescens subsp. dispar
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