Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MetFHomocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase domain protein; KEGG: mas:Mahau_0258 1.6e-66 homocysteine S-methyltransferase; K00547 homocysteine S-methyltransferase; Psort location: Cytoplasmic, score: 8.96; Belongs to the methylenetetrahydrofolate reductase family. (286 aa)    
Predicted Functional Partners:
MetH
KEGG: vpr:Vpar_1850 0. homocysteine S-methyltransferase; K00548 5-methyltetrahydrofolate--homocysteine methyltransferase; Psort location: Cytoplasmic, score: 9.97.
 
 0.999
folD
Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
    
 0.977
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.943
MetE
KEGG: pdn:HMPREF9137_0954 2.1e-144 methionine synthase, vitamin-B12 independent; Psort location: Cytoplasmic, score: 8.96.
  
  
 0.933
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
     
 0.909
metA
Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family.
  
  
 0.892
fhs
KEGG: vpr:Vpar_1289 5.2e-290 formate-tetrahydrofolate ligase; K01938 formate--tetrahydrofolate ligase; Psort location: Cytoplasmic, score: 8.96.
  
 
 0.813
KXB83815.1
Vitamin B12 dependent methionine synthase, activation domain protein; KEGG: sri:SELR_28110 2.3e-49 putative 5-methyltetrahydrofolate-homocysteine methyltransferase; Psort location: Cytoplasmic, score: 8.96.
  
  
 0.804
MetB
Putative cystathionine beta-lyase; KEGG: vpr:Vpar_0266 4.2e-194 Cys/Met metabolism pyridoxal-phosphate-dependent protein; K01760 cystathionine beta-lyase; Psort location: Cytoplasmic, score: 9.97.
  
 
 0.771
ackA
Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.
     
 0.725
Your Current Organism:
Veillonella dispar
NCBI taxonomy Id: 39778
Other names: ATCC 17748, DSM 20735, NCTC 11831, V. dispar, Veillonella alcalescens subsp. dispar
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