node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SMB77519.1 | SMB77521.1 | SAMN05660745_00170 | SAMN05660745_00172 | XTP/dITP diphosphohydrolase. | Transcriptional regulator, TetR family. | 0.755 |
SMB77519.1 | SMB78421.1 | SAMN05660745_00170 | SAMN05660745_01940 | XTP/dITP diphosphohydrolase. | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.880 |
SMB77519.1 | SMB80811.1 | SAMN05660745_00170 | SAMN05660745_00645 | XTP/dITP diphosphohydrolase. | GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.700 |
SMB77519.1 | SMB82557.1 | SAMN05660745_00170 | SAMN05660745_00845 | XTP/dITP diphosphohydrolase. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.902 |
SMB77519.1 | SMB84244.1 | SAMN05660745_00170 | SAMN05660745_01156 | XTP/dITP diphosphohydrolase. | IMP dehydrogenase. | 0.879 |
SMB77519.1 | SMB85211.1 | SAMN05660745_00170 | SAMN05660745_01382 | XTP/dITP diphosphohydrolase. | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | 0.878 |
SMB77519.1 | cmk | SAMN05660745_00170 | SAMN05660745_02400 | XTP/dITP diphosphohydrolase. | Cytidylate kinase. | 0.674 |
SMB77519.1 | guaA | SAMN05660745_00170 | SAMN05660745_01158 | XTP/dITP diphosphohydrolase. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.879 |
SMB77519.1 | mfd | SAMN05660745_00170 | SAMN05660745_00171 | XTP/dITP diphosphohydrolase. | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | 0.847 |
SMB77519.1 | ribBA | SAMN05660745_00170 | SAMN05660745_00694 | XTP/dITP diphosphohydrolase. | GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.747 |
SMB77521.1 | SMB77519.1 | SAMN05660745_00172 | SAMN05660745_00170 | Transcriptional regulator, TetR family. | XTP/dITP diphosphohydrolase. | 0.755 |
SMB77521.1 | mfd | SAMN05660745_00172 | SAMN05660745_00171 | Transcriptional regulator, TetR family. | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | 0.777 |
SMB78421.1 | SMB77519.1 | SAMN05660745_01940 | SAMN05660745_00170 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | XTP/dITP diphosphohydrolase. | 0.880 |
SMB78421.1 | SMB80811.1 | SAMN05660745_01940 | SAMN05660745_00645 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.408 |
SMB78421.1 | SMB82557.1 | SAMN05660745_01940 | SAMN05660745_00845 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.882 |
SMB78421.1 | SMB84244.1 | SAMN05660745_01940 | SAMN05660745_01156 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | IMP dehydrogenase. | 0.924 |
SMB78421.1 | SMB85211.1 | SAMN05660745_01940 | SAMN05660745_01382 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 5'-nucleotidase; Belongs to the 5'-nucleotidase family. | 0.879 |
SMB78421.1 | guaA | SAMN05660745_01940 | SAMN05660745_01158 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.945 |
SMB78421.1 | ribBA | SAMN05660745_01940 | SAMN05660745_00694 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.553 |
SMB80811.1 | SMB77519.1 | SAMN05660745_00645 | SAMN05660745_00170 | GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | XTP/dITP diphosphohydrolase. | 0.700 |