node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SMB77401.1 | hisA | SAMN05660745_00050 | SAMN05660745_01554 | Homoserine dehydrogenase. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | 0.723 |
SMB77401.1 | hisD | SAMN05660745_00050 | SAMN05660745_01547 | Homoserine dehydrogenase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.739 |
SMB77401.1 | hisE | SAMN05660745_00050 | SAMN05660745_00771 | Homoserine dehydrogenase. | phosphoribosyl-ATP pyrophosphatase. | 0.635 |
SMB77401.1 | hisF | SAMN05660745_00050 | SAMN05660745_01556 | Homoserine dehydrogenase. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | 0.804 |
SMB77401.1 | hisG | SAMN05660745_00050 | SAMN05660745_00772 | Homoserine dehydrogenase. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.705 |
SMB77401.1 | rpoC | SAMN05660745_00050 | SAMN05660745_01047 | Homoserine dehydrogenase. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.770 |
SMB81234.1 | hisB | SAMN05660745_00770 | SAMN05660745_01549 | Haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED. | Imidazoleglycerol-phosphate dehydratase. | 0.458 |
SMB81234.1 | hisE | SAMN05660745_00770 | SAMN05660745_00771 | Haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED. | phosphoribosyl-ATP pyrophosphatase. | 0.664 |
SMB81234.1 | hisG | SAMN05660745_00770 | SAMN05660745_00772 | Haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.527 |
hisA | SMB77401.1 | SAMN05660745_01554 | SAMN05660745_00050 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Homoserine dehydrogenase. | 0.723 |
hisA | hisB | SAMN05660745_01554 | SAMN05660745_01549 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Imidazoleglycerol-phosphate dehydratase. | 0.997 |
hisA | hisC | SAMN05660745_01554 | SAMN05660745_01548 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Histidinol phosphate aminotransferase apoenzyme; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.976 |
hisA | hisD | SAMN05660745_01554 | SAMN05660745_01547 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.997 |
hisA | hisE | SAMN05660745_01554 | SAMN05660745_00771 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | phosphoribosyl-ATP pyrophosphatase. | 0.960 |
hisA | hisF | SAMN05660745_01554 | SAMN05660745_01556 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | 0.999 |
hisA | hisG | SAMN05660745_01554 | SAMN05660745_00772 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.993 |
hisA | hisH | SAMN05660745_01554 | SAMN05660745_01553 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | rpoC | SAMN05660745_01554 | SAMN05660745_01047 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.598 |
hisB | SMB81234.1 | SAMN05660745_01549 | SAMN05660745_00770 | Imidazoleglycerol-phosphate dehydratase. | Haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED. | 0.458 |
hisB | hisA | SAMN05660745_01549 | SAMN05660745_01554 | Imidazoleglycerol-phosphate dehydratase. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | 0.997 |