STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
metXAHomoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (350 aa)    
Predicted Functional Partners:
SMB84339.1
O-acetylhomoserine sulfhydrylase.
 
 
 0.999
SMB77401.1
Homoserine dehydrogenase.
 
 
 0.944
ilvA
L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
  
 
 0.894
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.890
SMB83071.1
Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family.
    
 0.841
SMB84331.1
5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family.
     
 0.785
metE
Methionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
    
 0.758
SMB77911.1
Aspartate kinase; Belongs to the aspartokinase family.
   
 0.750
trpC
Indole-3-glycerol phosphate synthase; Belongs to the TrpC family.
   
 
  0.653
SMB83066.1
Serine O-acetyltransferase.
    
 0.594
Your Current Organism:
Corynebacterium glucuronolyticum
NCBI taxonomy Id: 39791
Other names: ATCC 51860, ATCC:51866 [[Corynebacterium seminale]], C. glucuronolyticum, CCUG 35055, CCUG:34780 [[Corynebacterium seminale]], CCUG:34888 [[Corynebacterium seminale]], CIP 104577, CIP:104297 [[Corynebacterium seminale]], Corynebacterium seminale, DMMZ 838, DSM 44120, DSM 44288 [[Corynebacterium seminale]], JCM 11612, JCM:10394 [[Corynebacterium seminale]], LMG 19047, LMG:19047, strain IBS B12915 [[Corynebacterium seminale]]
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.