| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Aave_0031 | Aave_0100 | Aave_0031 | Aave_0100 | acetyl-CoA acetyltransferase; KEGG: eba:p2A409 beta-ketothiolase protein; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | PFAM: acetyl-CoA hydrolase/transferase; KEGG: rpb:RPB_0503 acetyl-CoA hydrolase. | 0.910 |
| Aave_0031 | Aave_2463 | Aave_0031 | Aave_2463 | acetyl-CoA acetyltransferase; KEGG: eba:p2A409 beta-ketothiolase protein; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.907 |
| Aave_0031 | Aave_3247 | Aave_0031 | Aave_3247 | acetyl-CoA acetyltransferase; KEGG: eba:p2A409 beta-ketothiolase protein; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | 2-oxoglutarate dehydrogenase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). | 0.814 |
| Aave_0031 | acsA | Aave_0031 | Aave_1499 | acetyl-CoA acetyltransferase; KEGG: eba:p2A409 beta-ketothiolase protein; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.933 |
| Aave_0031 | glcB | Aave_0031 | Aave_0408 | acetyl-CoA acetyltransferase; KEGG: eba:p2A409 beta-ketothiolase protein; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. | 0.925 |
| Aave_0031 | sucC | Aave_0031 | Aave_4684 | acetyl-CoA acetyltransferase; KEGG: eba:p2A409 beta-ketothiolase protein; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | succinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.822 |
| Aave_0031 | sucD | Aave_0031 | Aave_4683 | acetyl-CoA acetyltransferase; KEGG: eba:p2A409 beta-ketothiolase protein; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | succinyl-CoA synthetase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.836 |
| Aave_0100 | Aave_0031 | Aave_0100 | Aave_0031 | PFAM: acetyl-CoA hydrolase/transferase; KEGG: rpb:RPB_0503 acetyl-CoA hydrolase. | acetyl-CoA acetyltransferase; KEGG: eba:p2A409 beta-ketothiolase protein; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | 0.910 |
| Aave_0100 | Aave_2201 | Aave_0100 | Aave_2201 | PFAM: acetyl-CoA hydrolase/transferase; KEGG: rpb:RPB_0503 acetyl-CoA hydrolase. | KEGG: pol:Bpro_3603 succinate dehydrogenase and fumarate reductase iron-sulfur protein; TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; PFAM: ferredoxin; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | 0.922 |
| Aave_0100 | Aave_2202 | Aave_0100 | Aave_2202 | PFAM: acetyl-CoA hydrolase/transferase; KEGG: rpb:RPB_0503 acetyl-CoA hydrolase. | KEGG: pol:Bpro_3602 succinate dehydrogenase, flavoprotein subunit; TIGRFAM: succinate dehydrogenase, flavoprotein subunit; succinate dehydrogenase or fumarate reductase, flavoprotein subunit; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; FAD dependent oxidoreductase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | 0.924 |
| Aave_0100 | Aave_2463 | Aave_0100 | Aave_2463 | PFAM: acetyl-CoA hydrolase/transferase; KEGG: rpb:RPB_0503 acetyl-CoA hydrolase. | Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.916 |
| Aave_0100 | Aave_2510 | Aave_0100 | Aave_2510 | PFAM: acetyl-CoA hydrolase/transferase; KEGG: rpb:RPB_0503 acetyl-CoA hydrolase. | KEGG: pol:Bpro_2161 methylmalonyl-CoA mutase; TIGRFAM: methylmalonyl-CoA mutase, large subunit; PFAM: methylmalonyl-CoA mutase; cobalamin B12-binding domain protein. | 0.965 |
| Aave_0100 | Aave_3247 | Aave_0100 | Aave_3247 | PFAM: acetyl-CoA hydrolase/transferase; KEGG: rpb:RPB_0503 acetyl-CoA hydrolase. | 2-oxoglutarate dehydrogenase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). | 0.916 |
| Aave_0100 | acsA | Aave_0100 | Aave_1499 | PFAM: acetyl-CoA hydrolase/transferase; KEGG: rpb:RPB_0503 acetyl-CoA hydrolase. | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.931 |
| Aave_0100 | glcB | Aave_0100 | Aave_0408 | PFAM: acetyl-CoA hydrolase/transferase; KEGG: rpb:RPB_0503 acetyl-CoA hydrolase. | Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. | 0.930 |
| Aave_0100 | sucC | Aave_0100 | Aave_4684 | PFAM: acetyl-CoA hydrolase/transferase; KEGG: rpb:RPB_0503 acetyl-CoA hydrolase. | succinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.939 |
| Aave_0100 | sucD | Aave_0100 | Aave_4683 | PFAM: acetyl-CoA hydrolase/transferase; KEGG: rpb:RPB_0503 acetyl-CoA hydrolase. | succinyl-CoA synthetase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.938 |
| Aave_2201 | Aave_0100 | Aave_2201 | Aave_0100 | KEGG: pol:Bpro_3603 succinate dehydrogenase and fumarate reductase iron-sulfur protein; TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; PFAM: ferredoxin; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | PFAM: acetyl-CoA hydrolase/transferase; KEGG: rpb:RPB_0503 acetyl-CoA hydrolase. | 0.922 |
| Aave_2201 | Aave_2202 | Aave_2201 | Aave_2202 | KEGG: pol:Bpro_3603 succinate dehydrogenase and fumarate reductase iron-sulfur protein; TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; PFAM: ferredoxin; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | KEGG: pol:Bpro_3602 succinate dehydrogenase, flavoprotein subunit; TIGRFAM: succinate dehydrogenase, flavoprotein subunit; succinate dehydrogenase or fumarate reductase, flavoprotein subunit; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; FAD dependent oxidoreductase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | 0.999 |
| Aave_2201 | Aave_2463 | Aave_2201 | Aave_2463 | KEGG: pol:Bpro_3603 succinate dehydrogenase and fumarate reductase iron-sulfur protein; TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; PFAM: ferredoxin; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. | Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.688 |