Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Aave_0899PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: pol:Bpro_1134 putative phosphomethylpyrimidine kinase. (318 aa)    
Predicted Functional Partners:
Aave_3071
KEGG: rfr:Rfer_2467 thiamine-phosphate diphosphorylase; TIGRFAM: thiamine-phosphate pyrophosphorylase; PFAM: thiamine monophosphate synthase.
 
 
 0.986
thiC
Hydroxymethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
 
 
 0.984
Aave_3067
KEGG: pol:Bpro_2331 phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1.
  
  
 
0.929
hemL
TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: pol:Bpro_1133 glutamate-1-semialdehyde-2,1-aminomutase.
  
  
 0.864
thiG
Thiazole-phosphate synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
  
 0.863
Aave_3069
TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: thiamineS protein; KEGG: bxe:Bxe_A0384 putative sulfur transfer protein involved in thiamine biosynthesis, ThiS.
  
  
 0.750
Aave_3860
[sulfur carrier protein ThiS] adenylyltransferase; PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; KEGG: rfr:Rfer_1307 UBA/ThiF-type NAD/FAD binding protein.
 
  
 0.689
Aave_0900
PFAM: Rubredoxin-type Fe(Cys)4 protein; KEGG: pol:Bpro_1135 rubredoxin-type Fe(Cys)4 protein.
  
    0.637
Aave_0897
Hypothetical protein; KEGG: rso:RSc2775 probable harpin-related protein.
       0.532
Aave_3525
Integral membrane sensor hybrid histidine kinase; PFAM: permease for cytosine/purines, uracil, thiamine, allantoin; response regulator receiver; ATP-binding region, ATPase domain protein; histidine kinase A domain protein; KEGG: pol:Bpro_1353 periplasmic sensor hybrid histidine kinase.
  
  
 0.526
Your Current Organism:
Acidovorax citrulli
NCBI taxonomy Id: 397945
Other names: A. citrulli AAC00-1, Acidovorax avenae subsp. citrulli AAC00-1, Acidovorax citrulli AAC00-1, Acidovorax citrulli str. AAC00-1, Acidovorax citrulli strain AAC00-1
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