| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Aave_0980 | Aave_0981 | Aave_0980 | Aave_0981 | PFAM: lipid A biosynthesis acyltransferase; KEGG: rfr:Rfer_3881 putative acyltransferase. | PFAM: lipid A biosynthesis acyltransferase; KEGG: pol:Bpro_0769 lipid A biosynthesis acyltransferase. | 0.989 |
| Aave_0980 | Aave_2820 | Aave_0980 | Aave_2820 | PFAM: lipid A biosynthesis acyltransferase; KEGG: rfr:Rfer_3881 putative acyltransferase. | Three-deoxy-D-manno-octulosonic-acid transferase domain protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | 0.955 |
| Aave_0980 | Aave_4785 | Aave_0980 | Aave_4785 | PFAM: lipid A biosynthesis acyltransferase; KEGG: rfr:Rfer_3881 putative acyltransferase. | KEGG: rfr:Rfer_4237 KpsF/GutQ family protein; TIGRFAM: KpsF/GutQ family protein; PFAM: CBS domain containing protein; sugar isomerase (SIS); Belongs to the SIS family. GutQ/KpsF subfamily. | 0.630 |
| Aave_0980 | kdsB | Aave_0980 | Aave_2562 | PFAM: lipid A biosynthesis acyltransferase; KEGG: rfr:Rfer_3881 putative acyltransferase. | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | 0.520 |
| Aave_0980 | lpxA | Aave_0980 | Aave_1835 | PFAM: lipid A biosynthesis acyltransferase; KEGG: rfr:Rfer_3881 putative acyltransferase. | acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.563 |
| Aave_0980 | lpxB | Aave_0980 | Aave_1836 | PFAM: lipid A biosynthesis acyltransferase; KEGG: rfr:Rfer_3881 putative acyltransferase. | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.710 |
| Aave_0980 | lpxC | Aave_0980 | Aave_0827 | PFAM: lipid A biosynthesis acyltransferase; KEGG: rfr:Rfer_3881 putative acyltransferase. | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. | 0.550 |
| Aave_0980 | lpxD | Aave_0980 | Aave_1833 | PFAM: lipid A biosynthesis acyltransferase; KEGG: rfr:Rfer_3881 putative acyltransferase. | UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | 0.663 |
| Aave_0980 | lpxK | Aave_0980 | Aave_2564 | PFAM: lipid A biosynthesis acyltransferase; KEGG: rfr:Rfer_3881 putative acyltransferase. | lipid-A-disaccharide kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). | 0.591 |
| Aave_0980 | metK | Aave_0980 | Aave_0979 | PFAM: lipid A biosynthesis acyltransferase; KEGG: rfr:Rfer_3881 putative acyltransferase. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.655 |
| Aave_0981 | Aave_0980 | Aave_0981 | Aave_0980 | PFAM: lipid A biosynthesis acyltransferase; KEGG: pol:Bpro_0769 lipid A biosynthesis acyltransferase. | PFAM: lipid A biosynthesis acyltransferase; KEGG: rfr:Rfer_3881 putative acyltransferase. | 0.989 |
| Aave_0981 | Aave_2820 | Aave_0981 | Aave_2820 | PFAM: lipid A biosynthesis acyltransferase; KEGG: pol:Bpro_0769 lipid A biosynthesis acyltransferase. | Three-deoxy-D-manno-octulosonic-acid transferase domain protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | 0.959 |
| Aave_0981 | Aave_4785 | Aave_0981 | Aave_4785 | PFAM: lipid A biosynthesis acyltransferase; KEGG: pol:Bpro_0769 lipid A biosynthesis acyltransferase. | KEGG: rfr:Rfer_4237 KpsF/GutQ family protein; TIGRFAM: KpsF/GutQ family protein; PFAM: CBS domain containing protein; sugar isomerase (SIS); Belongs to the SIS family. GutQ/KpsF subfamily. | 0.676 |
| Aave_0981 | kdsB | Aave_0981 | Aave_2562 | PFAM: lipid A biosynthesis acyltransferase; KEGG: pol:Bpro_0769 lipid A biosynthesis acyltransferase. | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | 0.522 |
| Aave_0981 | lpxA | Aave_0981 | Aave_1835 | PFAM: lipid A biosynthesis acyltransferase; KEGG: pol:Bpro_0769 lipid A biosynthesis acyltransferase. | acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.601 |
| Aave_0981 | lpxB | Aave_0981 | Aave_1836 | PFAM: lipid A biosynthesis acyltransferase; KEGG: pol:Bpro_0769 lipid A biosynthesis acyltransferase. | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.768 |
| Aave_0981 | lpxC | Aave_0981 | Aave_0827 | PFAM: lipid A biosynthesis acyltransferase; KEGG: pol:Bpro_0769 lipid A biosynthesis acyltransferase. | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. | 0.632 |
| Aave_0981 | lpxD | Aave_0981 | Aave_1833 | PFAM: lipid A biosynthesis acyltransferase; KEGG: pol:Bpro_0769 lipid A biosynthesis acyltransferase. | UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | 0.717 |
| Aave_0981 | lpxK | Aave_0981 | Aave_2564 | PFAM: lipid A biosynthesis acyltransferase; KEGG: pol:Bpro_0769 lipid A biosynthesis acyltransferase. | lipid-A-disaccharide kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). | 0.604 |
| Aave_0981 | metK | Aave_0981 | Aave_0979 | PFAM: lipid A biosynthesis acyltransferase; KEGG: pol:Bpro_0769 lipid A biosynthesis acyltransferase. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.655 |