Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (183 aa)    
Predicted Functional Partners:
aroB
3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
  
 0.998
aroE
Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
 
 
 0.977
cmk
Cytidylate kinase / 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate; Belongs to the cytidylate kinase family. Type 1 subfamily.
 
 
 0.974
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
  
 0.918
Aave_1000
TIGRFAM: type IV pilus secretin PilQ; PFAM: type II and III secretion system protein; NolW domain protein; Secretin/TonB, short N-terminal domain; KEGG: rfr:Rfer_2923 type II and III secretion system protein.
     
 0.840
Aave_1001
PFAM: Ig domain protein, group 1 domain protein; KEGG: rfr:Rfer_2924 Ig-like, group 1.
       0.839
Aave_0996
TIGRFAM: type IV pilus assembly protein PilM; KEGG: pol:Bpro_0781 type IV pilus assembly protein PilM.
     
 0.815
Aave_0998
PFAM: Pilus assembly protein, PilO; KEGG: pol:Bpro_0783 pilus assembly protein, PilO.
       0.810
Aave_0999
PFAM: Pilus assembly protein, PilQ; KEGG: pol:Bpro_0784 pilus assembly protein, PilQ.
       0.810
Aave_0997
PFAM: Fimbrial assembly family protein; KEGG: rfr:Rfer_2920 fimbrial assembly.
       0.807
Your Current Organism:
Acidovorax citrulli
NCBI taxonomy Id: 397945
Other names: A. citrulli AAC00-1, Acidovorax avenae subsp. citrulli AAC00-1, Acidovorax citrulli AAC00-1, Acidovorax citrulli str. AAC00-1, Acidovorax citrulli strain AAC00-1
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