| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Aave_0021 | Aave_0852 | Aave_0021 | Aave_0852 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). | 0.904 |
| Aave_0021 | Aave_3283 | Aave_0021 | Aave_3283 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). | PFAM: Prephenate dehydrogenase; 6-phosphogluconate dehydrogenase, NAD-binding; KEGG: rfr:Rfer_1568 prephenate dehydrogenase. | 0.446 |
| Aave_0021 | aroB | Aave_0021 | Aave_1003 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). | 0.954 |
| Aave_0583 | aroB | Aave_0583 | Aave_1003 | Anthranilate synthase, component II; TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: pol:Bpro_4455 glutamine amidotransferase of anthranilate synthase or para-aminobenzoate synthase. | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). | 0.850 |
| Aave_0583 | aroC | Aave_0583 | Aave_2995 | Anthranilate synthase, component II; TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: pol:Bpro_4455 glutamine amidotransferase of anthranilate synthase or para-aminobenzoate synthase. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.967 |
| Aave_0583 | aroE | Aave_0583 | Aave_0841 | Anthranilate synthase, component II; TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: pol:Bpro_4455 glutamine amidotransferase of anthranilate synthase or para-aminobenzoate synthase. | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.783 |
| Aave_0583 | aroK | Aave_0583 | Aave_1002 | Anthranilate synthase, component II; TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: pol:Bpro_4455 glutamine amidotransferase of anthranilate synthase or para-aminobenzoate synthase. | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. | 0.525 |
| Aave_0583 | cmk | Aave_0583 | Aave_3284 | Anthranilate synthase, component II; TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: pol:Bpro_4455 glutamine amidotransferase of anthranilate synthase or para-aminobenzoate synthase. | Cytidylate kinase / 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate; Belongs to the cytidylate kinase family. Type 1 subfamily. | 0.644 |
| Aave_0852 | Aave_0021 | Aave_0852 | Aave_0021 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). | 0.904 |
| Aave_0852 | Aave_3283 | Aave_0852 | Aave_3283 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). | PFAM: Prephenate dehydrogenase; 6-phosphogluconate dehydrogenase, NAD-binding; KEGG: rfr:Rfer_1568 prephenate dehydrogenase. | 0.446 |
| Aave_0852 | aroB | Aave_0852 | Aave_1003 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). | 0.954 |
| Aave_3283 | Aave_0021 | Aave_3283 | Aave_0021 | PFAM: Prephenate dehydrogenase; 6-phosphogluconate dehydrogenase, NAD-binding; KEGG: rfr:Rfer_1568 prephenate dehydrogenase. | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). | 0.446 |
| Aave_3283 | Aave_0852 | Aave_3283 | Aave_0852 | PFAM: Prephenate dehydrogenase; 6-phosphogluconate dehydrogenase, NAD-binding; KEGG: rfr:Rfer_1568 prephenate dehydrogenase. | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). | 0.446 |
| Aave_3283 | aroB | Aave_3283 | Aave_1003 | PFAM: Prephenate dehydrogenase; 6-phosphogluconate dehydrogenase, NAD-binding; KEGG: rfr:Rfer_1568 prephenate dehydrogenase. | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). | 0.897 |
| Aave_3283 | aroC | Aave_3283 | Aave_2995 | PFAM: Prephenate dehydrogenase; 6-phosphogluconate dehydrogenase, NAD-binding; KEGG: rfr:Rfer_1568 prephenate dehydrogenase. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.827 |
| Aave_3283 | aroE | Aave_3283 | Aave_0841 | PFAM: Prephenate dehydrogenase; 6-phosphogluconate dehydrogenase, NAD-binding; KEGG: rfr:Rfer_1568 prephenate dehydrogenase. | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.497 |
| Aave_3283 | aroK | Aave_3283 | Aave_1002 | PFAM: Prephenate dehydrogenase; 6-phosphogluconate dehydrogenase, NAD-binding; KEGG: rfr:Rfer_1568 prephenate dehydrogenase. | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. | 0.450 |
| Aave_3283 | aroQ | Aave_3283 | Aave_2302 | PFAM: Prephenate dehydrogenase; 6-phosphogluconate dehydrogenase, NAD-binding; KEGG: rfr:Rfer_1568 prephenate dehydrogenase. | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. | 0.434 |
| Aave_3283 | cmk | Aave_3283 | Aave_3284 | PFAM: Prephenate dehydrogenase; 6-phosphogluconate dehydrogenase, NAD-binding; KEGG: rfr:Rfer_1568 prephenate dehydrogenase. | Cytidylate kinase / 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate; Belongs to the cytidylate kinase family. Type 1 subfamily. | 0.976 |
| aroB | Aave_0021 | Aave_1003 | Aave_0021 | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). | 0.954 |