Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (354 aa)    
Predicted Functional Partners:
Aave_0328
PFAM: conserved hypothetical protein 701; KEGG: rfr:Rfer_3804 conserved hypothetical protein 701.
 
  
 0.951
ctaB
Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
     
 0.933
Aave_1374
Bacterioferritin; Iron-storage protein.
     
 0.911
Aave_1507
TIGRFAM: bacterioferritin; PFAM: Ferritin, Dps family protein; KEGG: pae:PA4235 bacterioferritin; Belongs to the bacterioferritin family.
     
 0.911
Aave_3866
PFAM: Rubrerythrin; Ferritin, Dps family protein; KEGG: reu:Reut_A2901 rubrerythrin:ferritin and Dps.
     
 0.911
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
  
 0.901
Aave_4735
PFAM: amine oxidase; KEGG: dar:Daro_3715 twin-arginine translocation pathway signal.
  
 
 0.852
cyaY
Frataxin family protein; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis.
    
 
 0.835
Aave_3001
Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region, ATPase domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein; KEGG: rso:RS03102 probable two-component sensor kinase transcription regulator protein.
   
  0.751
Aave_4079
ABC transporter-related protein; PFAM: ABC transporter, transmembrane region; ABC transporter-related protein; SMART: AAA ATPase; KEGG: pol:Bpro_3906 ABC transporter-related protein.
   
 
 0.706
Your Current Organism:
Acidovorax citrulli
NCBI taxonomy Id: 397945
Other names: A. citrulli AAC00-1, Acidovorax avenae subsp. citrulli AAC00-1, Acidovorax citrulli AAC00-1, Acidovorax citrulli str. AAC00-1, Acidovorax citrulli strain AAC00-1
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.