Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
cobB-2Silent information regulator protein Sir2; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class II subfamily. (309 aa)    
Predicted Functional Partners:
Aave_3713
KEGG: pfl:PFL_2193 hypothetical protein.
   
   0.814
Aave_3236
KEGG: pol:Bpro_2939 exodeoxyribonuclease I; PFAM: Exonuclease, RNase T and DNA polymerase III; Exonuclease C-terminal domain protein; SMART: Exonuclease.
       0.783
Aave_4628
PFAM: nuclear protein SET; SMART: SET-related domain protein; KEGG: rfr:Rfer_3954 nuclear protein SET.
  
 
 0.653
Aave_0188
PFAM: Glu/Leu/Phe/Val dehydrogenase, C terminal; Glu/Leu/Phe/Val dehydrogenase, dimerisation region; KEGG: pol:Bpro_3239 Glu/Leu/Phe/Val dehydrogenase, C terminal; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
    
 0.571
Aave_3237
TIGRFAM: lytic murein transglycosylase; PFAM: Peptidoglycan-binding domain 1 protein; KEGG: rfr:Rfer_0327 lytic murein transglycosylase.
       0.559
Aave_2164
PFAM: histone deacetylase superfamily; KEGG: pol:Bpro_3145 histone deacetylase superfamily.
    
 0.531
Aave_2450
PFAM: histone deacetylase superfamily; KEGG: pol:Bpro_2707 histone deacetylase superfamily.
    
 0.531
Aave_0974
TIGRFAM: cytidyltransferase-related domain; PFAM: NUDIX hydrolase; cytidylyltransferase; KEGG: xcv:XCV0734 nicotinamide-nucleotide adenylyltransferase.
  
    0.525
Aave_3234
GAF modulated sigma54 specific transcriptional regulator, Fis family; PFAM: sigma-54 factor, interaction domain-containing protein; helix-turn-helix, Fis-type; GAF domain protein; SMART: AAA ATPase; KEGG: bcn:Bcen_3245 GAF modulated sigma54 specific transcriptional regulator, fis family.
  
    0.521
Aave_1320
KEGG: pol:Bpro_3186 hypothetical protein.
   
    0.518
Your Current Organism:
Acidovorax citrulli
NCBI taxonomy Id: 397945
Other names: A. citrulli AAC00-1, Acidovorax avenae subsp. citrulli AAC00-1, Acidovorax citrulli AAC00-1, Acidovorax citrulli str. AAC00-1, Acidovorax citrulli strain AAC00-1
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