| node1 | node2 | node1 annotation | node2 annotation | score |
| Aave_1411 | Aave_3631 | PFAM: Alkaline phosphatase; KEGG: rfr:Rfer_1326 alkaline phosphatase. | PFAM: GTP cyclohydrolase I; KEGG: pol:Bpro_0869 GTP cyclohydrolase I. | 0.922 |
| Aave_1411 | Aave_4226 | PFAM: Alkaline phosphatase; KEGG: rfr:Rfer_1326 alkaline phosphatase. | KEGG: rfr:Rfer_0814 dihydroneopterin aldolase. | 0.915 |
| Aave_1860 | Aave_1974 | TIGRFAM: FolC bifunctional protein; PFAM: cytoplasmic peptidoglycan synthetases domain protein; Mur ligase, middle domain protein; KEGG: rfr:Rfer_2686 FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK; KEGG: rfr:Rfer_2508 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. | 0.743 |
| Aave_1860 | Aave_2618 | TIGRFAM: FolC bifunctional protein; PFAM: cytoplasmic peptidoglycan synthetases domain protein; Mur ligase, middle domain protein; KEGG: rfr:Rfer_2686 FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.993 |
| Aave_1860 | Aave_3631 | TIGRFAM: FolC bifunctional protein; PFAM: cytoplasmic peptidoglycan synthetases domain protein; Mur ligase, middle domain protein; KEGG: rfr:Rfer_2686 FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | PFAM: GTP cyclohydrolase I; KEGG: pol:Bpro_0869 GTP cyclohydrolase I. | 0.726 |
| Aave_1860 | Aave_4226 | TIGRFAM: FolC bifunctional protein; PFAM: cytoplasmic peptidoglycan synthetases domain protein; Mur ligase, middle domain protein; KEGG: rfr:Rfer_2686 FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | KEGG: rfr:Rfer_0814 dihydroneopterin aldolase. | 0.681 |
| Aave_1974 | Aave_1860 | TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK; KEGG: rfr:Rfer_2508 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. | TIGRFAM: FolC bifunctional protein; PFAM: cytoplasmic peptidoglycan synthetases domain protein; Mur ligase, middle domain protein; KEGG: rfr:Rfer_2686 FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | 0.743 |
| Aave_1974 | Aave_2618 | TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK; KEGG: rfr:Rfer_2508 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.999 |
| Aave_1974 | Aave_3631 | TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK; KEGG: rfr:Rfer_2508 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. | PFAM: GTP cyclohydrolase I; KEGG: pol:Bpro_0869 GTP cyclohydrolase I. | 0.973 |
| Aave_1974 | Aave_4226 | TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK; KEGG: rfr:Rfer_2508 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. | KEGG: rfr:Rfer_0814 dihydroneopterin aldolase. | 0.994 |
| Aave_1996 | Aave_2989 | PFAM: HemY domain protein; KEGG: pol:Bpro_3661 putative porphyrin biosynthesis related protein. | KEGG: rfr:Rfer_2656 hypothetical protein. | 0.760 |
| Aave_1996 | Aave_3608 | PFAM: HemY domain protein; KEGG: pol:Bpro_3661 putative porphyrin biosynthesis related protein. | KEGG: pol:Bpro_1295 putative lipoprotein. | 0.775 |
| Aave_1996 | Aave_3642 | PFAM: HemY domain protein; KEGG: pol:Bpro_3661 putative porphyrin biosynthesis related protein. | KEGG: rfr:Rfer_1293 hypothetical protein. | 0.756 |
| Aave_1996 | Aave_4226 | PFAM: HemY domain protein; KEGG: pol:Bpro_3661 putative porphyrin biosynthesis related protein. | KEGG: rfr:Rfer_0814 dihydroneopterin aldolase. | 0.728 |
| Aave_2618 | Aave_1860 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | TIGRFAM: FolC bifunctional protein; PFAM: cytoplasmic peptidoglycan synthetases domain protein; Mur ligase, middle domain protein; KEGG: rfr:Rfer_2686 FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | 0.993 |
| Aave_2618 | Aave_1974 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK; KEGG: rfr:Rfer_2508 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. | 0.999 |
| Aave_2618 | Aave_3631 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | PFAM: GTP cyclohydrolase I; KEGG: pol:Bpro_0869 GTP cyclohydrolase I. | 0.968 |
| Aave_2618 | Aave_4226 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | KEGG: rfr:Rfer_0814 dihydroneopterin aldolase. | 0.994 |
| Aave_2989 | Aave_1996 | KEGG: rfr:Rfer_2656 hypothetical protein. | PFAM: HemY domain protein; KEGG: pol:Bpro_3661 putative porphyrin biosynthesis related protein. | 0.760 |
| Aave_2989 | Aave_3608 | KEGG: rfr:Rfer_2656 hypothetical protein. | KEGG: pol:Bpro_1295 putative lipoprotein. | 0.753 |