STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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dphBDiphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. (274 aa)    
Predicted Functional Partners:
fusA
Translation elongation factor aEF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...]
  
 0.965
Cmaq_1133
Diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family.
  
 0.943
Cmaq_1530
TIGRFAM: putative ATP binding protein; PFAM: protein of unknown function DUF71 ATP-binding region; KEGG: sto:ST2048 hypothetical protein.
 
 
 0.908
rpl37ae
Ribosomal protein L37a; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
  
  
 0.786
Cmaq_1245
TIGRFAM: cytidyltransferase-related domain; PFAM: cytidylyltransferase; Protein of unknown function DUF357; KEGG: pai:PAE0683 cytidyltransferase.
       0.720
Cmaq_0980
PFAM: KH type 1 domain protein; KEGG: hbu:Hbut_1405 universally conserved protein.
  
    0.709
Cmaq_0582
PFAM: Translation initiation factor IF2/IF5; KEGG: pis:Pisl_1439 translation initiation factor IF5.
  
    0.686
Cmaq_0343
PFAM: protein of unknown function Met10; KEGG: pis:Pisl_0714 protein of unknown function Met10.
 
  
 0.600
rps4e
PFAM: RNA-binding S4 domain protein; Ribosomal protein S4E, central; KEGG: pis:Pisl_0560 ribosomal protein S4E, central; Belongs to the eukaryotic ribosomal protein eS4 family.
  
    0.594
fen
XPG I; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genom [...]
  
     0.593
Your Current Organism:
Caldivirga maquilingensis
NCBI taxonomy Id: 397948
Other names: C. maquilingensis IC-167, Caldivirga maquilingensis DSM 13496, Caldivirga maquilingensis IC-167, Caldivirga maquilingensis JCM 10307, Caldivirga maquilingensis str. IC-167, Caldivirga maquilingensis strain IC-167
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