SFM46743.1 protein (Thermodesulforhabdus norvegica)

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

SFM46743.1

Tripartite ATP-independent transporter solute receptor, DctP family. (335 aa)

Predicted Functional Partners:

SFM46702.1

0.925

SFM46725.1

0.912

SFM53153.1

0.872

SFM47003.1

0.866

SFN05861.1

0.860

SFM46980.1

0.859

SFM42609.1

0.852

SFM42598.1

0.835

SFN05844.1

0.831

SFM88536.1

0.799

Your Current Organism:

Thermodesulforhabdus norvegica

NCBI taxonomy Id: 39841
Other names: DSM 9990, Desulforhabdus acetothermus, T. norvegica, Thermodesulforhabdus norvegicus, strain A8444

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SFM42598.1	SFM42609.1	SAMN05660836_00183	SAMN05660836_00184	TRAP-type C4-dicarboxylate transport system, small permease component.	TRAP transporter, DctM subunit.	0.981
SFM42598.1	SFM46702.1	SAMN05660836_00183	SAMN05660836_00372	TRAP-type C4-dicarboxylate transport system, small permease component.	TRAP transporter, DctM subunit.	0.920
SFM42598.1	SFM46725.1	SAMN05660836_00183	SAMN05660836_00373	TRAP-type C4-dicarboxylate transport system, small permease component.	TRAP-type C4-dicarboxylate transport system, small permease component.	0.848
SFM42598.1	SFM46743.1	SAMN05660836_00183	SAMN05660836_00374	TRAP-type C4-dicarboxylate transport system, small permease component.	Tripartite ATP-independent transporter solute receptor, DctP family.	0.835
SFM42598.1	SFM47003.1	SAMN05660836_00183	SAMN05660836_00386	TRAP-type C4-dicarboxylate transport system, small permease component.	Tripartite ATP-independent transporter, DctM component.	0.920
SFM42598.1	SFM53153.1	SAMN05660836_00183	SAMN05660836_00687	TRAP-type C4-dicarboxylate transport system, small permease component.	TRAP transporter, DctM subunit.	0.921
SFM42598.1	SFM88536.1	SAMN05660836_00183	SAMN05660836_01807	TRAP-type C4-dicarboxylate transport system, small permease component.	TRAP transporter, DctM subunit.	0.811
SFM42598.1	SFN05844.1	SAMN05660836_00183	SAMN05660836_02501	TRAP-type C4-dicarboxylate transport system, small permease component.	TRAP-type C4-dicarboxylate transport system, small permease component.	0.525
SFM42598.1	SFN05861.1	SAMN05660836_00183	SAMN05660836_02502	TRAP-type C4-dicarboxylate transport system, small permease component.	TRAP transporter, DctM subunit.	0.923
SFM42609.1	SFM42598.1	SAMN05660836_00184	SAMN05660836_00183	TRAP transporter, DctM subunit.	TRAP-type C4-dicarboxylate transport system, small permease component.	0.981
SFM42609.1	SFM46725.1	SAMN05660836_00184	SAMN05660836_00373	TRAP transporter, DctM subunit.	TRAP-type C4-dicarboxylate transport system, small permease component.	0.883
SFM42609.1	SFM46743.1	SAMN05660836_00184	SAMN05660836_00374	TRAP transporter, DctM subunit.	Tripartite ATP-independent transporter solute receptor, DctP family.	0.852
SFM42609.1	SFM46980.1	SAMN05660836_00184	SAMN05660836_00385	TRAP transporter, DctM subunit.	TRAP-type C4-dicarboxylate transport system, small permease component.	0.917
SFM42609.1	SFM53153.1	SAMN05660836_00184	SAMN05660836_00687	TRAP transporter, DctM subunit.	TRAP transporter, DctM subunit.	0.555
SFM42609.1	SFN05844.1	SAMN05660836_00184	SAMN05660836_02501	TRAP transporter, DctM subunit.	TRAP-type C4-dicarboxylate transport system, small permease component.	0.914
SFM46702.1	SFM42598.1	SAMN05660836_00372	SAMN05660836_00183	TRAP transporter, DctM subunit.	TRAP-type C4-dicarboxylate transport system, small permease component.	0.920
SFM46702.1	SFM46725.1	SAMN05660836_00372	SAMN05660836_00373	TRAP transporter, DctM subunit.	TRAP-type C4-dicarboxylate transport system, small permease component.	0.969
SFM46702.1	SFM46743.1	SAMN05660836_00372	SAMN05660836_00374	TRAP transporter, DctM subunit.	Tripartite ATP-independent transporter solute receptor, DctP family.	0.925
SFM46702.1	SFM46980.1	SAMN05660836_00372	SAMN05660836_00385	TRAP transporter, DctM subunit.	TRAP-type C4-dicarboxylate transport system, small permease component.	0.928
SFM46702.1	SFM53153.1	SAMN05660836_00372	SAMN05660836_00687	TRAP transporter, DctM subunit.	TRAP transporter, DctM subunit.	0.697

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

17

average node degree:

3.09

avg. local clustering coefficient:

0.787

expected number of edges:

10

PPI enrichment p-value:

0.0391

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0055085

Transmembrane transport

10 of 249

0.85

0.84

1.28e-05

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042626

ATPase-coupled transmembrane transporter activity

5 of 57

1.19

1.12

0.00033

GO:0140359

ABC-type transporter activity

4 of 39

1.26

1.04

0.0016

GO:0005524

ATP binding

10 of 261

0.83

0.82

1.05e-05

GO:0022857

Transmembrane transporter activity

8 of 210

0.83

0.76

9.66e-05

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016020

Membrane

10 of 571

0.49

0.38

0.0041

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2923

Transcription regulators MarR/SlyA-like, and ABC transporter transmembrane region

4 of 5

2.15

2.51

9.61e-06

CL:2919

Mixed, incl. ABC transporter transmembrane region, and ABC transporter, CbiO/EcfA subunit

5 of 31

1.46

1.59

5.78e-05

CL:2914

Mixed, incl. ABC transporters, and Latent infection - Other responses of Mtb to phagocytosis

9 of 108

1.17

1.51

1.53e-07

CL:2915

Mixed, incl. ABC transporters, and Latent infection - Other responses of Mtb to phagocytosis

8 of 93

1.18

1.45

1.18e-06

CL:2916

Mixed, incl. Latent infection - Other responses of Mtb to phagocytosis, and ABC transporters

7 of 82

1.18

1.34

9.66e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

adc02010

ABC transporters

6 of 90

1.07

0.97

0.00042

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1222449

Mtb iron assimilation by chelation

2 of 15

1.37

0.62

0.0483

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005886

Plasma membrane

7 of 236

0.72

0.49

0.0111

GOCC:0016020

Membrane

8 of 319

0.65

0.45

0.0111

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-1278

Translocase

3 of 10

1.73

1.29

0.0020

KW-0067

ATP-binding

10 of 211

0.92

1.02

4.39e-07

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR017871

ABC transporter-like, conserved site

10 of 60

1.47

2.74

1.49e-11

IPR003439

ABC transporter-like, ATP-binding domain

10 of 67

1.42

2.57

2.05e-11

IPR003593

AAA+ ATPase domain

10 of 84

1.32

2.18

1.12e-10

IPR027417

P-loop containing nucleoside triphosphate hydrolase

10 of 157

1.05

1.32

3.16e-08

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00382

ATPases associated with a variety of cellular activities

10 of 81

1.34

2.29

2.19e-11

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