SFN03585.1 protein (Thermodesulforhabdus norvegica)

Nodes:

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

Coexpression

Experiments

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[Homology]

Score

SFN03585.1

Pyruvate ferredoxin oxidoreductase gamma subunit. (198 aa)

Predicted Functional Partners:

SFN03543.1

0.988

SFN03553.1

0.975

SFM45383.1

0.962

SFM51800.1

0.962

SFN03570.1

0.954

SFM45359.1

0.923

SFM51777.1

0.922

SFN01564.1

0.892

SFM51762.1

0.877

SFM81305.1

0.875

Your Current Organism:

Thermodesulforhabdus norvegica

NCBI taxonomy Id: 39841
Other names: DSM 9990, Desulforhabdus acetothermus, T. norvegica, Thermodesulforhabdus norvegicus, strain A8444

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SFM45359.1	SFM45383.1	SAMN05660836_00309	SAMN05660836_00310	Pyruvate ferredoxin oxidoreductase alpha subunit.	Pyruvate ferredoxin oxidoreductase beta subunit.	0.999
SFM45359.1	SFM51762.1	SAMN05660836_00309	SAMN05660836_00625	Pyruvate ferredoxin oxidoreductase alpha subunit.	Pyruvate ferredoxin oxidoreductase delta subunit.	0.982
SFM45359.1	SFM51777.1	SAMN05660836_00309	SAMN05660836_00626	Pyruvate ferredoxin oxidoreductase alpha subunit.	Pyruvate ferredoxin oxidoreductase alpha subunit.	0.858
SFM45359.1	SFM51800.1	SAMN05660836_00309	SAMN05660836_00627	Pyruvate ferredoxin oxidoreductase alpha subunit.	Pyruvate ferredoxin oxidoreductase beta subunit.	0.999
SFM45359.1	SFM81305.1	SAMN05660836_00309	SAMN05660836_01573	Pyruvate ferredoxin oxidoreductase alpha subunit.	Pyruvate ferredoxin oxidoreductase delta subunit.	0.984
SFM45359.1	SFN01564.1	SAMN05660836_00309	SAMN05660836_02331	Pyruvate ferredoxin oxidoreductase alpha subunit.	Glutamate synthase (NADPH) GltB3 subunit.	0.898
SFM45359.1	SFN03543.1	SAMN05660836_00309	SAMN05660836_02405	Pyruvate ferredoxin oxidoreductase alpha subunit.	Ketoisovalerate ferredoxin oxidoreductase, beta subunit.	0.996
SFM45359.1	SFN03570.1	SAMN05660836_00309	SAMN05660836_02407	Pyruvate ferredoxin oxidoreductase alpha subunit.	NADPH-dependent glutamate synthase beta chain.	0.838
SFM45359.1	SFN03585.1	SAMN05660836_00309	SAMN05660836_02408	Pyruvate ferredoxin oxidoreductase alpha subunit.	Pyruvate ferredoxin oxidoreductase gamma subunit.	0.923
SFM45383.1	SFM45359.1	SAMN05660836_00310	SAMN05660836_00309	Pyruvate ferredoxin oxidoreductase beta subunit.	Pyruvate ferredoxin oxidoreductase alpha subunit.	0.999
SFM45383.1	SFM51762.1	SAMN05660836_00310	SAMN05660836_00625	Pyruvate ferredoxin oxidoreductase beta subunit.	Pyruvate ferredoxin oxidoreductase delta subunit.	0.985
SFM45383.1	SFM51777.1	SAMN05660836_00310	SAMN05660836_00626	Pyruvate ferredoxin oxidoreductase beta subunit.	Pyruvate ferredoxin oxidoreductase alpha subunit.	0.999
SFM45383.1	SFM51800.1	SAMN05660836_00310	SAMN05660836_00627	Pyruvate ferredoxin oxidoreductase beta subunit.	Pyruvate ferredoxin oxidoreductase beta subunit.	0.864
SFM45383.1	SFM81305.1	SAMN05660836_00310	SAMN05660836_01573	Pyruvate ferredoxin oxidoreductase beta subunit.	Pyruvate ferredoxin oxidoreductase delta subunit.	0.987
SFM45383.1	SFN01564.1	SAMN05660836_00310	SAMN05660836_02331	Pyruvate ferredoxin oxidoreductase beta subunit.	Glutamate synthase (NADPH) GltB3 subunit.	0.890
SFM45383.1	SFN03553.1	SAMN05660836_00310	SAMN05660836_02406	Pyruvate ferredoxin oxidoreductase beta subunit.	Pyruvate ferredoxin oxidoreductase alpha subunit.	0.998
SFM45383.1	SFN03570.1	SAMN05660836_00310	SAMN05660836_02407	Pyruvate ferredoxin oxidoreductase beta subunit.	NADPH-dependent glutamate synthase beta chain.	0.860
SFM45383.1	SFN03585.1	SAMN05660836_00310	SAMN05660836_02408	Pyruvate ferredoxin oxidoreductase beta subunit.	Pyruvate ferredoxin oxidoreductase gamma subunit.	0.962
SFM51762.1	SFM45359.1	SAMN05660836_00625	SAMN05660836_00309	Pyruvate ferredoxin oxidoreductase delta subunit.	Pyruvate ferredoxin oxidoreductase alpha subunit.	0.982
SFM51762.1	SFM45383.1	SAMN05660836_00625	SAMN05660836_00310	Pyruvate ferredoxin oxidoreductase delta subunit.	Pyruvate ferredoxin oxidoreductase beta subunit.	0.985

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Network Stats

number of nodes:

11

number of edges:

34

average node degree:

6.18

avg. local clustering coefficient:

0.728

expected number of edges:

14

PPI enrichment p-value:

3.99e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016575

Histone deacetylation

4 of 62

2.02

2.15

4.11e-05

GO:0070828

Heterochromatin organization

4 of 68

1.98

2.1

4.74e-05

GO:0050872

White fat cell differentiation

3 of 22

2.34

1.97

0.00019

GO:0045444

Fat cell differentiation

4 of 124

1.72

1.59

0.00034

GO:0006325

Chromatin organization

7 of 523

1.34

1.54

1.89e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0001222

Transcription corepressor binding

6 of 58

2.22

4.11

2.51e-09

GO:0042826

Histone deacetylase binding

4 of 130

1.7

1.55

0.00040

GO:0098882

Structural constituent of presynaptic active zone

2 of 6

2.73

1.51

0.0018

GO:0051287

NAD binding

3 of 64

1.88

1.39

0.0016

GO:0008134

Transcription factor binding

7 of 660

1.24

1.35

3.15e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035098

ESC/E(Z) complex

4 of 12

2.73

3.71

1.20e-07

GO:0016581

NuRD complex

4 of 18

2.56

3.42

3.22e-07

GO:0017053

Transcription repressor complex

5 of 82

2.0

2.96

3.76e-07

GO:0005667

Transcription regulator complex

10 of 518

1.5

2.86

8.60e-12

GO:0016589

NURF complex

3 of 8

2.78

2.8

6.96e-06

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7538

D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain, and Histone methyltransferase activity (H3-K9 specific)

4 of 7

2.97

3.81

1.01e-07

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map05220

Chronic myeloid leukemia

6 of 87

2.05

3.82

2.68e-09

map04330

Notch signaling pathway

4 of 69

1.97

2.31

1.45e-05

map05200

Pathways in cancer

6 of 558

1.24

1.33

4.55e-05

map04310

Wnt signaling pathway

3 of 205

1.38

0.78

0.0190

map04218

Cellular senescence

3 of 198

1.39

0.78

0.0190

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-3214841

PKMTs methylate histone lysines

5 of 63

2.11

3.02

5.36e-07

MAP-8943724

Regulation of PTEN gene transcription

5 of 71

2.06

2.97

5.36e-07

MAP-6804758

Regulation of TP53 Activity through Acetylation

4 of 40

2.21

2.74

3.58e-06

MAP-3214815

HDACs deacetylate histones

4 of 41

2.2

2.73

3.58e-06

MAP-4641265

Repression of WNT target genes

3 of 13

2.57

2.54

1.84e-05

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001688

Cochlear ganglion

2 of 3

3.03

1.2

0.0069

BTO:0003667

Inner hair cell

2 of 6

2.73

1.19

0.0069

BTO:0004725

Embryonic fibroblast

3 of 142

1.53

0.76

0.0276

BTO:0000379

Embryo

5 of 1013

0.9

0.51

0.0345

BTO:0000174

Embryonic structure

6 of 1491

0.81

0.49

0.0276

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0035098

ESC/E(Z) complex

4 of 11

2.77

3.6

2.07e-07

GOCC:0098831

Presynaptic active zone cytoplasmic component

3 of 15

2.51

2.23

6.89e-05

GOCC:0098681

Synaptic ribbon

2 of 3

3.03

1.67

0.00096

GOCC:0098684

Photoreceptor ribbon synapse

2 of 10

2.51

1.27

0.0046

GOCC:0090545

CHD-type complex

2 of 11

2.47

1.26

0.0048

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF12265

Histone-binding protein RBBP4 or subunit C of CAF1 complex

3 of 3

3.21

2.83

7.69e-06

PF02826

D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain

3 of 4

3.08

2.82

7.69e-06

PF08504

Runx inhibition domain

2 of 3

3.03

1.44

0.0025

PF00853

Runt domain

2 of 3

3.03

1.44

0.0025

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