STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
purHBifunctional purine biosynthesis protein purH; KEGG: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme, MGS domain protein; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; HAMAP : Bifunctional purine biosynthesis protein purH; SMART: AICARFT/IMPCHase bienzyme, MGS domain protein. (514 aa)    
Predicted Functional Partners:
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
 0.999
Bccel_3705
TIGRFAM: phosphoribosylformylglycinamidine synthase; KEGG: phosphoribosylformylglycinamidine synthase; PFAM: AIR synthase related protein domain protein, AIR synthase related protein.
 
 
 0.998
purD
Phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain-containing protein, Phosphoribosylglycinamide synthetase, N-domain-containing protein, Phosphoribosylglycinamide synthetase, C-domain-containing protein; TIGRFAM: phosphoribosylamine/glycine ligase; HAMAP : Phosphoribosylamine--glycine ligase; KEGG: phosphoribosylamine--glycine ligase; Belongs to the GARS family.
 
 0.994
purM
Phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein domain protein, AIR synthase related protein; TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; HAMAP : phosphoribosylformylglycinamidine cyclo-ligase; KEGG: phosphoribosylaminoimidazole synthetase.
 
  
 0.989
Bccel_1321
SMART: Adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; KEGG: adenylosuccinate lyase; PFAM: Lyase 1, N-terminal, Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
  
 0.988
purF
Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
 
 0.985
purC
PFAM: SAICAR synthetase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; HAMAP : Phosphoribosylaminoimidazole-succinocarboxamide synthase; KEGG: phosphoribosylaminoimidazole-succinocarboxamide synthase.
  
 0.980
purE
Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
 
  
 0.978
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.977
Bccel_1565
KEGG: IMP dehydrogenase/GMP reductase; PFAM: IMP dehydrogenase/GMP reductase, CBS domain containing protein.
  
 
 0.972
Your Current Organism:
Pseudobacteroides cellulosolvens
NCBI taxonomy Id: 398512
Other names: Bacteroides cellulosolvens ATCC 35603, Bacteroides cellulosolvens DSM 2933, P. cellulosolvens ATCC 35603 = DSM 2933, Pseudobacteroides cellulosolvens ATCC 35603 = DSM 2933, Pseudobacteroides cellulosolvens DSM 2933 = ATCC 35603
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.